Endomyocardial Fibrosis Secondary to Chronic Eosinophilic Leukemia: Case Report

Yasmin Tourinho Delmondes Trindade, Caio Oliveira Bastos, Mariana Garcez da Cruz, Leda Maria Delmondes Freitas Trindade, Luiz Flávio Galvão Gonçalves, José Augusto Soares Barreto Filho, Milena dos Santos Barros Campos
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Abstract

Endomyocardial fibrosis (EMF) is characterized by fibrosis of the endomyocardium of one or both ventricles and atrioventricular valves. Progressive fibrosis leads to irreversible restrictive cardiomyopathy, progressing to heart failure (HF), thromboembolic phenomena, and arrhythmias. It is one of the main complications of chronic eosinophilic leukemia (CEL), resulting from intense eosinophilic infiltration into cardiac tissue. This case is of a 34-year-old male patient with past medical history of CEL, who developed EMF and severe heart failure, NYHA (New York Heart Association) IV, and underwent endocardectomy and mitral and tricuspid valvuloplasty. After the procedure, he improved to NYHA II, initiated cardiovascular rehabilitation, and returned to daily activities.
继发于慢性嗜酸性粒细胞白血病的心内膜纤维化:病例报告
心内膜纤维化(EMF)的特征是一个或两个心室和房室瓣的心内膜纤维化。进行性纤维化会导致不可逆的限制性心肌病,进而发展为心力衰竭(HF)、血栓栓塞现象和心律失常。这是慢性嗜酸性粒细胞白血病(CEL)的主要并发症之一,是嗜酸性粒细胞大量浸润心脏组织所致。本病例是一名 34 岁的男性患者,既往有 CEL 病史,出现 EMF 和严重心力衰竭,NYHA(纽约心脏协会)IV 级,接受了心内膜切除术、二尖瓣和三尖瓣成形术。术后,他的病情好转为 NYHA II 级,开始进行心血管康复治疗,并恢复了日常活动。
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