P.119 NIRS regional oxygen saturation based cerebrovascular reactivity in the recovery from moderate/severe TBI

A Gomez, L. Froese, T Bergmann, AS Sainbhi, N Vakitbilir, A Islam, KY Stein, I Marquez, Y Ibrahim, F. Zeiler
{"title":"P.119 NIRS regional oxygen saturation based cerebrovascular reactivity in the recovery from moderate/severe TBI","authors":"A Gomez, L. Froese, T Bergmann, AS Sainbhi, N Vakitbilir, A Islam, KY Stein, I Marquez, Y Ibrahim, F. Zeiler","doi":"10.1017/cjn.2024.221","DOIUrl":null,"url":null,"abstract":"Background: Near-infrared spectroscopy (NIRS) regional cerebral oxygen saturation (rSO2) based cerebrovascular reactivity (CVR) indicies have enable the entirely non-invasive continuous monitoring. This study aims to compare CVR in those recovering from moderate/severe TBI to a health control group. Methods: In this prospective cohort study the cerebral oxygen CVR index, COx_a (using rSO2 and arterial blood pressure), was measured in subjects with moderate/severe TBI at follow-up. COx_a was also measured in a group of healthy controls. CVR was compared within and between these groups using conventional statistics. Results: A total of 101 heathy subject were recruited for this study along with 29 TBI patients. In the health cohort COx_a was not statistically different between males and females or in the dominate and non-dominate hemisphere. The TBI cohort, COx_a was not statistically different between first and last available follow up. Surprisingly, CVR as measured by COx_a was statistically better in those recovering from TBI than in the healthy cohort. Conclusions: In the prospective cohort study, CVR as measured by NIRS based methods, was found to be more active in those recovering from TBI than in a healthy cohort. This study may indicate that, in those that survive TBI, CVR may be enhanced as a neuroprotective measure.","PeriodicalId":9571,"journal":{"name":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","volume":"1 10","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1017/cjn.2024.221","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Near-infrared spectroscopy (NIRS) regional cerebral oxygen saturation (rSO2) based cerebrovascular reactivity (CVR) indicies have enable the entirely non-invasive continuous monitoring. This study aims to compare CVR in those recovering from moderate/severe TBI to a health control group. Methods: In this prospective cohort study the cerebral oxygen CVR index, COx_a (using rSO2 and arterial blood pressure), was measured in subjects with moderate/severe TBI at follow-up. COx_a was also measured in a group of healthy controls. CVR was compared within and between these groups using conventional statistics. Results: A total of 101 heathy subject were recruited for this study along with 29 TBI patients. In the health cohort COx_a was not statistically different between males and females or in the dominate and non-dominate hemisphere. The TBI cohort, COx_a was not statistically different between first and last available follow up. Surprisingly, CVR as measured by COx_a was statistically better in those recovering from TBI than in the healthy cohort. Conclusions: In the prospective cohort study, CVR as measured by NIRS based methods, was found to be more active in those recovering from TBI than in a healthy cohort. This study may indicate that, in those that survive TBI, CVR may be enhanced as a neuroprotective measure.
P.119 中度/重度创伤性脑损伤恢复过程中基于区域血氧饱和度的近红外光谱脑血管反应能力
背景:基于近红外光谱(NIRS)区域脑氧饱和度(rSO2)的脑血管反应性(CVR)指标实现了完全无创的连续监测。本研究旨在比较中度/重度创伤性脑损伤康复者与健康对照组的 CVR。方法:在这项前瞻性队列研究中,对中度/重度创伤性脑损伤患者进行了随访,测量了脑氧CVR指数COx_a(使用rSO2和动脉血压)。同时还测量了一组健康对照组的 COx_a。采用常规统计方法对这些组内和组间的 CVR 进行了比较。结果:本研究共招募了 101 名健康受试者和 29 名创伤性脑损伤患者。在健康组中,COx_a 在男性和女性之间、优势半球和非优势半球之间没有统计学差异。在 TBI 群体中,COx_a 在第一次和最后一次随访之间没有统计学差异。令人惊讶的是,根据 COx_a 测量的心血管恢复能力,创伤性脑损伤康复者在统计学上优于健康人群。结论:在前瞻性队列研究中,通过基于近红外光谱的方法测量发现,创伤性脑损伤康复者的 CVR 比健康人群更活跃。这项研究可能表明,在创伤性脑损伤幸存者中,CVR 作为一种神经保护措施可能会得到加强。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信