Vitamin D, Alzheimer's disease and related dementia.

Q1 Agricultural and Biological Sciences

Advances in Food and Nutrition Research Pub Date : 2024-01-01 Epub Date: 2024-01-05 DOI:10.1016/bs.afnr.2023.12.003

M Kyla Shea, Andrew Y Xuan, Sarah L Booth

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Abstract

Vitamin D has been proposed as a potential strategy to mitigate age-related cognitive decline and dementia, including Alzheimer's dementia, the predominant type of dementia. Rodent studies have provided insight into the potential mechanisms underlying the role of vitamin D in Alzheimer's disease and dementia. However, inconsistencies with respect to age, sex, and genetic background of the rodent models used poses some limitations regarding scientific rigor and translation. Several human observational studies have evaluated the association of vitamin D status with cognitive decline and dementia, and the results are conflicting. Randomized clinical trials of vitamin D supplementation have included cognitive outcomes. However, most of the available trials have not been designed specifically to test the effect of vitamin D on age-related cognitive decline and dementia, so it remains questionable how much additional vitamin D will improve cognitive performance. Here we evaluate the strengths and limitations of the available evidence regarding the role of vitamin D in AD, cognitive decline, dementia.

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维生素 D、阿尔茨海默病和相关痴呆症。

维生素 D 被认为是缓解与年龄有关的认知能力下降和痴呆症（包括痴呆症的主要类型阿尔茨海默氏症）的一种潜在策略。啮齿类动物研究让人们深入了解了维生素 D 在阿尔茨海默病和痴呆症中发挥作用的潜在机制。然而，所使用的啮齿类动物模型在年龄、性别和遗传背景方面的不一致性给科学的严谨性和转化带来了一些限制。有几项人类观察性研究评估了维生素 D 状态与认知能力下降和痴呆症的关系，结果相互矛盾。维生素 D 补充剂的随机临床试验包括认知结果。然而，现有的大多数试验并不是专门为测试维生素 D 对老年性认知功能衰退和痴呆症的影响而设计的，因此额外补充维生素 D 能在多大程度上改善认知能力仍是个问题。在此，我们评估了现有证据中有关维生素 D 在老年痴呆症、认知能力下降和痴呆症中作用的优势和局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Food and Nutrition Research Agricultural and Biological Sciences-Food Science

CiteScore

8.50

自引率

0.00%

发文量