Iron and neuromelanin imaging in basal ganglia circuitry in Parkinson's disease with freezing of gait

IF 2.1 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Youmin Zhang , Chencheng Zhang , Xinhui Wang , Yu Liu , Zhijia Jin , E. Mark Haacke , Naying He , Dianyou Li , Fuhua Yan
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Abstract

Objective

This study aimed to examine the structural alterations of the deep gray matter (DGM) in the basal ganglia circuitry of Parkinson's disease (PD) patients with freezing of gait (FOG) using quantitative susceptibility mapping (QSM) and neuromelanin-sensitive magnetic resonance imaging (NM-MRI).

Methods

Twenty-five (25) PD patients with FOG (PD-FOG), 22 PD patients without FOG (PD-nFOG), and 30 age- and sex-matched healthy controls (HCs) underwent 3-dimensional multi-echo gradient recalled echo and NM-MRI scanning. The mean volume and susceptibility of the DGM on QSM data and the relative contrast (NMRC-SNpc) and volume (NMvolume-SNpc) of the substantia nigra pars compacta on NM-MRI were analyzed among groups. A multiple linear regression analysis was performed to explore the associations of FOG severity with MRI measurements and disease stage.

Results

The PD-FOG group showed higher susceptibility in the bilateral caudal substantia nigra (SN) compared to the HC group. Both the PD-FOG and PD-nFOG groups showed lower volumes than the HC group in the bilateral caudate and putamen as determined from the QSM data. The NMvolume-SNpc on NM-MRI in the PD-FOG group was significantly lower than in the HC and PD-nFOG groups. Both the PD-FOG and PD-nFOG groups showed significantly decreased NMRC-SNpc.

Conclusions

The PD-FOG patients showed abnormal neostriatum atrophy, increases in iron deposition in the SN, and lower NMvolume-SNpc. The structural alterations of the DGM in the basal ganglia circuits could lead to the abnormal output of the basal ganglia circuit to trigger the FOG in PD patients.

帕金森病伴步态冻结患者基底神经节回路中的铁和神经褐素成像。
研究目的本研究旨在使用定量易感性图谱(QSM)和神经黑素敏感性磁共振成像(NM-MRI)检查帕金森病(PD)患者基底节回路深部灰质(DGM)的结构改变:25名患有步态障碍的PD患者(PD-FOG)、22名不患有步态障碍的PD患者(PD-nFOG)以及30名年龄和性别匹配的健康对照组(HCs)接受了三维多回波梯度召回回波和NM-MRI扫描。分析了各组间 QSM 数据中 DGM 的平均体积和易感性,以及 NM-MRI 中黑质致密旁的相对对比度(NMRC-SNpc)和体积(NMvolume-SNpc)。为了探讨FOG严重程度与MRI测量和疾病分期之间的关联,研究人员进行了多元线性回归分析:结果:PD-FOG组与HC组相比,双侧尾黑质(SN)的易感性更高。根据 QSM 数据,PD-FOG 组和 PD-nFOG 组的双侧尾状体和普鲁士门体积均低于 HC 组。PD-FOG 组 NM-MRI 上的 NMvolume-SNpc 显著低于 HC 组和 PD-nFOG 组。PD-FOG组和PD-nFOG组的NMRC-SNpc均明显减少:结论:PD-FOG 患者表现出异常的新纹状体萎缩、SN 中铁沉积增加以及 NMvolume-SNpc 降低。基底节回路中DGM的结构改变可能导致基底节回路输出异常,从而引发PD患者的FOG。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Magnetic resonance imaging
Magnetic resonance imaging 医学-核医学
CiteScore
4.70
自引率
4.00%
发文量
194
审稿时长
83 days
期刊介绍: Magnetic Resonance Imaging (MRI) is the first international multidisciplinary journal encompassing physical, life, and clinical science investigations as they relate to the development and use of magnetic resonance imaging. MRI is dedicated to both basic research, technological innovation and applications, providing a single forum for communication among radiologists, physicists, chemists, biochemists, biologists, engineers, internists, pathologists, physiologists, computer scientists, and mathematicians.
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