Public Health Impact and Cost-Effectiveness Analysis of 4-Component Meningococcal Serotype B Vaccination for Infants in France.

IF 2 Q2 ECONOMICS
PharmacoEconomics Open Pub Date : 2024-07-01 Epub Date: 2024-05-23 DOI:10.1007/s41669-024-00488-5
Gérard de Pouvourville, Manon Breau-Brunel, Véronique Loncle-Provot, Ekkehard Beck, Loïg Gaugain, Gaëlle Nachbaur, Céline Pribil
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引用次数: 0

Abstract

Background and objectives: In France, meningococcal serogroup B (MenB) is the most common serogroup causing invasive meningococcal disease (IMD) in infants and young children. Our objective was to illustrate the impact of model choices on health outcomes and the cost-effectiveness of infant vaccination with the multicomponent meningococcal serogroup B vaccine (4CMenB) versus no vaccine in France.

Methods: A previously published dynamic transmission-based cost-effectiveness model was adapted for the French context using updated, French-specific demographic, epidemiological, and cost data. IMD incidence and long-term sequelae were derived through analysis of French healthcare and surveillance databases. A collective perspective over a 100-year time horizon was adopted, with a discount rate of 2.5%, reduced to 1.5% after the first 30 years. Deterministic and probabilistic sensitivity and scenario analyses were performed.

Results: In the base case analysis, infant vaccination with 4CMenB avoided 3101 MenB IMD cases in infants aged < 1 year (- 54%) and 6845 cases in all age groups (- 21%). The estimated incremental cost-effectiveness ratio was €316,272/quality-adjusted life-year (QALY) but was highly sensitive to the types of sequelae included, MenB incidence, vaccine effectiveness parameters, and consideration of life-expectancy in IMD survivors (range: €65,272/QALY to €493,218/QALY).

Conclusions: Using economic models compliant with French methodology guidelines, 4CMenB does not seem cost-effective; however, results are sensitive to model choices and 4CMenB immunization is an effective strategy to prevent MenB IMD cases and to improve quality of life and economic burden associated with MenB IMD treatment, especially with regard to long-term sequelae.

法国婴儿接种四联脑膜炎球菌血清 B 型疫苗的公共卫生影响和成本效益分析。
背景和目的:在法国,B 型脑膜炎球菌血清群 (MenB) 是导致婴幼儿侵袭性脑膜炎球菌病 (IMD) 的最常见血清群。我们的目标是说明模型选择对健康结果的影响,以及在法国婴儿接种多组分脑膜炎球菌血清 B 群疫苗 (4CMenB) 与不接种疫苗的成本效益:方法:利用最新的法国特定人口、流行病学和成本数据,对之前发布的基于动态传播的成本效益模型进行了调整,使其适用于法国的情况。IMD 发病率和长期后遗症是通过分析法国医疗保健和监控数据库得出的。采用了 100 年时间跨度的集体视角,贴现率为 2.5%,头 30 年后降至 1.5%。进行了确定性和概率敏感性及情景分析:结果:在基础案例分析中,婴儿接种 4CMenB 疫苗可避免 3101 例 MenB IMD 病例:使用符合法国方法指南的经济模型,4CMenB 似乎并不具有成本效益;然而,结果对模型选择很敏感,4CMenB 免疫接种是预防男婴痴呆症病例、改善与男婴痴呆症治疗相关的生活质量和经济负担(尤其是长期后遗症)的有效策略。
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来源期刊
CiteScore
3.50
自引率
0.00%
发文量
64
审稿时长
8 weeks
期刊介绍: PharmacoEconomics - Open focuses on applied research on the economic implications and health outcomes associated with drugs, devices and other healthcare interventions. The journal includes, but is not limited to, the following research areas:Economic analysis of healthcare interventionsHealth outcomes researchCost-of-illness studiesQuality-of-life studiesAdditional digital features (including animated abstracts, video abstracts, slide decks, audio slides, instructional videos, infographics, podcasts and animations) can be published with articles; these are designed to increase the visibility, readership and educational value of the journal’s content. In addition, articles published in PharmacoEconomics -Open may be accompanied by plain language summaries to assist readers who have some knowledge of, but not in-depth expertise in, the area to understand important medical advances.All manuscripts are subject to peer review by international experts. Letters to the Editor are welcomed and will be considered for publication.
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