Dental management of long-term childhood cancer survivors: a systematic review.

IF 2.3 Q2 DENTISTRY, ORAL SURGERY & MEDICINE
K Seremidi, S Gizani, G Dahllöf, M Barr-Agholme, D Kloukos, G Tsilingaridis
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引用次数: 0

Abstract

Purpose: Critically review and summarise existing knowledge on prevalence of oral, dental, and craniofacial side-effects of antineoplastic treatment in childhood cancer survivors (CCS).

Methods: A literature search was conducted for studies reporting on children aged 4-19 years treated for any type of malignancy up to the age of 15 years and for whom, at the time of the examination, more than 8 months have elapsed since the end of treatment. Data regarding dental late effects on teeth and craniofacial complex were collected and mean prevalence of each defect was reported.

Results: From the 800 articles identified, 17 studies fulfilled inclusion criteria and were included. A total of 983 CCS were examined, with the total number of healthy controls being 1266 children. Haematological malignancy was the most prevalent diagnosis with the age at diagnosis ranging between 0-15 years. Multiple antineoplastic protocols were implemented with the elapsed time being 8 months up to 17 years. One-third of CCS experienced at least one late effect, with corresponding value for the control group being below 25%. Among the defects identified clinically, microdontia, hypodontia and enamel developmental defects were recorded in 1/4 of CCS. Impaired root growth and agenesis were the two defects mostly recorded radiographically. The effect on dental maturity and on salivary glands was unclear.

Conclusion: CCS are at risk of developing dental late effects because of their disease and its treatment and therefore, routine periodic examinations are essential to record their development and provide comprehensive oral healthcare.

儿童癌症长期幸存者的牙科管理:系统综述。
目的:对儿童癌症幸存者(CCS)口腔、牙齿和颅面抗肿瘤治疗副作用患病率的现有知识进行批判性回顾和总结:方法:对文献进行检索,研究对象为 4-19 岁接受过任何类型恶性肿瘤治疗的 15 岁以下儿童,且检查时其治疗结束时间已超过 8 个月。研究人员收集了有关牙科治疗后期对牙齿和颅面复合体影响的数据,并报告了每种缺陷的平均发生率:结果:在确定的 800 篇文章中,有 17 项研究符合纳入标准并被纳入。共有 983 名儿童颅面综合征患者接受了检查,健康对照组儿童总数为 1266 人。血液恶性肿瘤是最常见的诊断,诊断年龄在 0-15 岁之间。他们采用了多种抗肿瘤方案,治疗时间从 8 个月到 17 年不等。三分之一的儿童癌症患者至少出现过一次晚期效应,而对照组的相应数值低于25%。在临床上发现的缺陷中,1/4的儿童有小牙合、牙合不足和釉质发育缺陷。牙根生长受阻和牙根发育不全是影像学上记录最多的两种缺陷。对牙齿成熟度和唾液腺的影响尚不明确:结论:由于疾病及其治疗方法,儿童先天性心脏病患者有出现牙齿晚期影响的风险,因此,常规定期检查对记录他们的发育情况和提供全面的口腔保健至关重要。
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来源期刊
European Archives of Paediatric Dentistry
European Archives of Paediatric Dentistry DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
4.40
自引率
9.10%
发文量
81
期刊介绍: The aim and scope of European Archives of Paediatric Dentistry (EAPD) is to promote research in all aspects of dentistry for children, including interceptive orthodontics and studies on children and young adults with special needs. The EAPD focuses on the publication and critical evaluation of clinical and basic science research related to children. The EAPD will consider clinical case series reports, followed by the relevant literature review, only where there are new and important findings of interest to Paediatric Dentistry and where details of techniques or treatment carried out and the success of such approaches are given.
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