Amniotic sac diameter reference interval in early pregnancy between 7 and 10 weeks' gestation.

IF 6.1 1区医学 Q1 ACOUSTICS

Ultrasound in Obstetrics & Gynecology Pub Date : 2024-12-01 Epub Date: 2024-10-30 DOI:10.1002/uog.27705

S A Solangon, S Nijjar, L V De Braud, J Knez, L Berg, E Jauniaux, D Jurkovic

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引用次数: 0

Abstract

Objective: To establish a normal reference interval for amniotic sac diameter (ASD) between 7 + 0 and 9 + 6 weeks' gestation and its relative size in relation to gestational sac diameter (GSD) and the embryo crown-rump length (CRL).

Methods: This was a prospective, cross-sectional study of consecutive women presenting to the Early Pregnancy Unit, University College Hospital, London, UK, between August 2022 and June 2023. We included live, normally sited, singleton pregnancies with a normal 20-week anomaly scan. We collected 120 cases per gestational week, from 7 + 0 to 9 + 6 weeks' gestation, totaling 360 cases. We performed an inter- and intraobserver variability assessment in the measurement of mean ASD in 30 patients. Regression analyses were used to establish reference intervals for GSD and CRL, ASD and CRL, GSD and ASD, and GSD/ASD ratio and CRL. A fitted regression line was calculated, along with a 90% prediction interval and R² value.

Results: There was good interobserver agreement (mean ± SD difference, 0.007 ± 1.105 mm (95% limits of agreement (LoA), -2.160 to 2.174 mm)) and good intraobserver agreement for Observer A (mean ± SD difference, -0.080 ± 0.741 mm (95% LoA, -1.532 to 1.372 mm)) and Observer B (mean ± SD difference, -0.014 ± 0.919 mm (95% LoA, -1.814 to 1.786 mm)) in the measurement of mean ASD. Regression analyses showed a statistically significant association between each pair of values (P < 0.001 for all). There was a significant quadratic association between mean GSD and CRL (R² = 56%), mean GSD and ASD (R² = 60%) and GSD/ASD ratio and CRL (R² = 68%), and a significant cubic association between mean ASD and CRL (R² = 90%). The regression equations were used to quantify the values of ASD and GSD/ASD ratios for a range of CRL values and gestational ages.

Conclusion: Our study has produced comprehensive reference intervals for amniotic sac size in early pregnancy, which could be used in routine clinical practice. © 2024 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

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妊娠 7 至 10 周的早孕期羊膜囊参考间隔。

目的确定妊娠 7 至 10 周羊膜囊测量的正常参考区间，以及羊膜囊与妊娠囊和胚胎的相对大小：这是一项前瞻性横断面研究，研究对象是 2022 年 8 月至 2023 年 6 月期间到伦敦大学洛杉矶分校医院早孕科就诊的连续女性。我们纳入了20周异常扫描正常的活产、正常妊娠、单胎妊娠。我们在每个孕周收集了 120 个病例，共计 360 个病例。我们对 30 例患者的平均 ASD 测量结果进行了观察者间和观察者内变异性评估。我们使用回归分析来确定 GSD 与 CRL、ASD 与 CRL、GSD 与 ASD 以及 GSD:ASD 与 CRL 比率的参考区间。计算了拟合回归线、90% 预测区间和 R2 值：结果：在测量 30 名患者的平均 ASD 时，观察者 A（0.007 ± 1.105 (-2.160 to 2.174)）和观察者 B（-0.014 ± 0.919 (-1.814 to 1.786)）之间的观察者间一致性良好（差异为 0.007mm ± 1.105 (95%CI-2.160-2.174)），观察者 B 之间的观察者内一致性良好（-0.014 ± 0.919 (-1.814 to 1.786)）。回归分析表明，每对数值（所有 p 值均为 2 = 56%）与平均 GSD 和 ASD（R2 = 60）之间存在高度统计学意义上的显著关联，ASD 与 CRL 之间存在显著的立方关联（R2 = 90%），GSD 与 ASD 比值与 CRL 之间存在显著的二次关联（R2 = 68%）。回归方程用于量化一系列 CRL 值和胎龄（天数）的 ASD 值和 GSD 与 ASD 比值：我们的研究得出了孕早期羊膜囊大小的综合参考区间，可用于常规临床实践。本文受版权保护。保留所有权利。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ultrasound in Obstetrics & Gynecology 医学-妇产科学

CiteScore

12.30

自引率

14.10%

发文量

891

审稿时长

1 months

期刊介绍： Ultrasound in Obstetrics & Gynecology (UOG) is the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) and is considered the foremost international peer-reviewed journal in the field. It publishes cutting-edge research that is highly relevant to clinical practice, which includes guidelines, expert commentaries, consensus statements, original articles, and systematic reviews. UOG is widely recognized and included in prominent abstract and indexing databases such as Index Medicus and Current Contents.