A cross species thermoelectric and spatiotemporal analysis of alternans in live explanted hearts using dual voltage-calcium fluorescence optical mapping.

IF 2.3 4区 医学 Q3 BIOPHYSICS
Anna Crispino, Alessandro Loppini, Ilija Uzelac, Shahriar Iravanian, Neal K Bhatia, Michael Burke, Simonetta Filippi, Flavio H Fenton, Alessio Gizzi
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引用次数: 0

Abstract

Objective.Temperature plays a crucial role in influencing the spatiotemporal dynamics of the heart. Electrical instabilities due to specific thermal conditions typically lead to early period-doubling bifurcations and beat-to-beat alternans. These pro-arrhythmic phenomena manifest in voltage and calcium traces, resulting in compromised contractile behaviors. In such intricate scenario, dual optical mapping technique was used to uncover unexplored multi-scale and nonlinear couplings, essential for early detection and understanding of cardiac arrhythmia.Approach.We propose a methodological analysis of synchronized voltage-calcium signals for detecting alternans, restitution curves, and spatiotemporal alternans patterns under different thermal conditions, based on integral features calculation. To validate our approach, we conducted a cross-species investigation involving rabbit and guinea pig epicardial ventricular surfaces and human endocardial tissue under pacing-down protocols.Main results.We show that the proposed integral feature, as the area under the curve, could be an easily applicable indicator that may enhance the predictability of the onset and progression of cardiac alternans. Insights into spatiotemporal correlation analysis of characteristic spatial lengths across different heart species were further provided.Significance.Exploring cross-species thermoelectric features contributes to understanding temperature-dependent proarrhythmic regimes and their implications on coupled spatiotemporal voltage-calcium dynamics. The findings provide preliminary insights and potential strategies for enhancing arrhythmia detection and treatment.

利用双电压-钙荧光光学图谱对活体移植心脏的交变进行跨物种热电和时空分析。
目的温度在影响心脏时空动态方面起着至关重要的作用。由特定热条件引起的电不稳定性通常会导致早期周期加倍分岔和搏动交替。这些助长心律失常的现象表现在电压和钙描记上,导致收缩行为受损。在这种错综复杂的情况下,双光学映射技术被用来揭示尚未探索的多尺度和非线性耦合,这对早期检测和了解心律失常至关重要。我们提出了一种基于积分特征计算的同步电压-钙信号分析方法,用于检测不同热条件下的交替、恢复曲线和时空交替模式。为了验证我们的方法,我们进行了一项跨物种调查,涉及起搏下降协议下的兔子和豚鼠心外膜心室表面以及人类心内膜组织。我们的研究表明,所提出的积分特征,即曲线下面积,是一个易于应用的指标,可以提高对心脏交替起搏和进展的可预测性。我们还对不同心脏物种特征空间长度的时空相关性分析提供了进一步的见解。探索跨物种的热电特征有助于理解温度依赖性心律失常前兆及其对电压-钙耦合时空动力学的影响。这些发现为加强心律失常的检测和治疗提供了初步见解和潜在策略。
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来源期刊
Physiological measurement
Physiological measurement 生物-工程:生物医学
CiteScore
5.50
自引率
9.40%
发文量
124
审稿时长
3 months
期刊介绍: Physiological Measurement publishes papers about the quantitative assessment and visualization of physiological function in clinical research and practice, with an emphasis on the development of new methods of measurement and their validation. Papers are published on topics including: applied physiology in illness and health electrical bioimpedance, optical and acoustic measurement techniques advanced methods of time series and other data analysis biomedical and clinical engineering in-patient and ambulatory monitoring point-of-care technologies novel clinical measurements of cardiovascular, neurological, and musculoskeletal systems. measurements in molecular, cellular and organ physiology and electrophysiology physiological modeling and simulation novel biomedical sensors, instruments, devices and systems measurement standards and guidelines.
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