Burden of Disease Study of Patients with Neovascular Age-Related Macular Degeneration in Spain.

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2024-07-01 Epub Date: 2024-05-21 DOI:10.1007/s40123-024-00960-9

Maximino J Abraldes, Pilar Calvo, María Gámez Lechuga, María Merino, Teresa Martín Lorenzo, Paulina Maravilla-Herrera, Beatriz Gil Jiménez, José M Ruiz-Moreno

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引用次数: 0

Abstract

Introduction: Neovascular age-related macular degeneration (nAMD) is a progressive retinal disease that causes severe and irreversible vision loss. The disease can therefore have a significant impact on the life of patients' and their families. The aim of this study was to evaluate the socio-economic burden of nAMD in Spain.

Methods: The annual cost per patient with nAMD was estimated for the first, second, and third year (or beyond) of treatment since diagnosis. Several cost categories were considered including direct healthcare costs (DHC), direct non-healthcare costs (DNHC), labor productivity losses (LPL), and intangible costs (IC) related to loss of quality of life. The average annual cost per patient was estimated by assigning a unit price or financial proxy to the resources consumed per patient. Reference year of costs was 2021.

Results: The mean annual cost of nAMD was estimated at €17,265, €15,403, and €14,465 per patient in the first, second, and third year of treatment after diagnosis. There was an additional one-off cost of €744 associated with the diagnosis of nAMD. DHC accounted for most of the total annual cost per patient independent of the year of treatment since diagnosis (48% in year 1; 42% in year 2; 39% in year 3). Similarly, DNHC had an important contribution to the total costs (32% in year 1; 35% in year 2; 37% in year 3), followed by IC (20% in year 1; 23% in year 2; 24% in year 3), while the contribution of patients' LPL was minimal.

Conclusion: This study estimated a high economic burden associated with nAMD for patients and their families, the healthcare system, and society at large. There is a need to improve the management of these patients to reduce the impact of nAMD disease progression.

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查看原文本刊更多论文

西班牙新生血管性老年黄斑变性患者疾病负担研究。

导言：新生血管性老年黄斑变性（nAMD）是一种渐进性视网膜疾病，会导致严重且不可逆的视力丧失。因此，这种疾病会对患者及其家人的生活产生重大影响。本研究旨在评估 nAMD 在西班牙造成的社会经济负担：方法：估算了每位 nAMD 患者在确诊后第一年、第二年和第三年（或之后）的治疗费用。考虑了多个成本类别，包括直接医疗成本 (DHC)、直接非医疗成本 (DNHC)、劳动生产率损失 (LPL) 以及与生活质量损失相关的无形成本 (IC)。每位患者的年均成本是通过对每位患者所消耗的资源进行单价或财务替代估算得出的。成本参考年为 2021 年：在确诊后的第一年、第二年和第三年，每名患者的 nAMD 平均年度成本分别为 17,265 欧元、15,403 欧元和 14,465 欧元。与 nAMD 诊断相关的额外一次性费用为 744 欧元。DHC占每位患者年度总费用的大部分，与确诊后的治疗年份无关（第1年占48%；第2年占42%；第3年占39%）。同样，DNHC 对总成本也有重要贡献（第 1 年为 32%；第 2 年为 35%；第 3 年为 37%），其次是 IC（第 1 年为 20%；第 2 年为 23%；第 3 年为 24%），而患者 LPL 的贡献则微乎其微：本研究估计，nAMD 给患者及其家庭、医疗系统和整个社会带来了沉重的经济负担。有必要改善对这些患者的管理，以减少 nAMD 疾病进展的影响。

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. 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