The use of effect biomarkers in chemical mixtures risk assessment – Are they still important?

IF 2.3 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Mutation research. Genetic toxicology and environmental mutagenesis Pub Date : 2024-05-01 DOI:10.1016/j.mrgentox.2024.503768

Carina Ladeira

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引用次数: 0

Abstract

Human epidemiological studies with biomarkers of effect play an invaluable role in identifying health effects with chemical exposures and in disease prevention. Effect biomarkers that measure genetic damage are potent tools to address the carcinogenic and/or mutagenic potential of chemical exposures, increasing confidence in regulatory risk assessment decision-making processes. The micronucleus (MN) test is recognized as one of the most successful and reliable assays to assess genotoxic events, which are associated with exposures that may cause cancer. To move towards the next generation risk assessment is crucial to establish bridges between standard approaches, new approach methodologies (NAMs) and tools for increase the mechanistically-based biological plausibility in human studies, such as the adverse outcome pathways (AOPs) framework. This paper aims to highlight the still active role of MN as biomarker of effect in the evolution and applicability of new methods and approaches in human risk assessment, with the positive consequence, that the new methods provide a deeper knowledge of the mechanistically-based biology of these endpoints.

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在化学混合物风险评估中使用效应生物标志物--它们仍然重要吗？

使用效应生物标志物进行的人类流行病学研究在确定化学品暴露对健康的影响和预防疾病方面发挥着不可估量的作用。测量遗传损伤的效应生物标志物是解决化学品暴露致癌和/或诱变潜力的有效工具，可增强监管风险评估决策过程的信心。微核试验（MN）被公认为是评估基因毒性事件最成功、最可靠的方法之一，而基因毒性事件与可能致癌的暴露有关。要进行下一代风险评估，就必须在标准方法、新方法（NAMs）和工具（如不良结果途径（AOPs）框架）之间建立桥梁，以提高人类研究中基于机理的生物学可信度。本文旨在强调 MN 作为生物效应标志物在人类风险评估新方法和方法的演变和适用性方面仍然发挥着积极作用，其积极结果是，新方法提供了对这些终点基于机理的生物学的更深入了解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mutation research. Genetic toxicology and environmental mutagenesis 生物-毒理学

CiteScore

3.80

自引率

5.30%

发文量

审稿时长

105 days

期刊介绍： Mutation Research - Genetic Toxicology and Environmental Mutagenesis (MRGTEM) publishes papers advancing knowledge in the field of genetic toxicology. Papers are welcomed in the following areas: New developments in genotoxicity testing of chemical agents (e.g. improvements in methodology of assay systems and interpretation of results). Alternatives to and refinement of the use of animals in genotoxicity testing. Nano-genotoxicology, the study of genotoxicity hazards and risks related to novel man-made nanomaterials. Studies of epigenetic changes in relation to genotoxic effects. The use of structure-activity relationships in predicting genotoxic effects. The isolation and chemical characterization of novel environmental mutagens. The measurement of genotoxic effects in human populations, when accompanied by quantitative measurements of environmental or occupational exposures. The application of novel technologies for assessing the hazard and risks associated with genotoxic substances (e.g. OMICS or other high-throughput approaches to genotoxicity testing). MRGTEM is now accepting submissions for a new section of the journal: Current Topics in Genotoxicity Testing, that will be dedicated to the discussion of current issues relating to design, interpretation and strategic use of genotoxicity tests. This section is envisaged to include discussions relating to the development of new international testing guidelines, but also to wider topics in the field. The evaluation of contrasting or opposing viewpoints is welcomed as long as the presentation is in accordance with the journal''s aims, scope, and policies.