Impact of inflammatory bowel disease on women's reproductive life: a questionnaire-based study.

IF 3.9 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Therapeutic Advances in Gastroenterology Pub Date : 2024-05-18 eCollection Date: 2024-01-01 DOI:10.1177/17562848241249440

Fabiana Zingone, Alessandro Borsato, Daria Maniero, Francesco Della Loggia, Greta Lorenzon, Annalisa Zanini, Cristina Canova, Brigida Barberio, Edoardo Vincenzo Savarino

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Abstract

Background: Inflammatory bowel diseases (IBDs) have a peak incidence between the second and fourth decades of life and can affect women's reproductive life.

Objectives: Our study aimed to assess the impact of IBD on the reproductive life of female patients with this condition.

Design: Cross-sectional study.

Methods: Women with IBD followed at our IBD Unit and a group of healthy controls were enrolled. Data on reproductive life were collected using a dedicated questionnaire.

Results: The study included 457 women, of whom 228 had IBD, and 229 age-matched healthy controls. No differences were found in the use of contraceptives, infertility, and endometriosis. The risk of spontaneous and voluntary abortions was significantly higher in IBD patients than in healthy controls [odds ratio (OR) 2 and 3.62, respectively]. The risk of obstetrical complications in the IBD population was more than six times higher in patients who experienced disease reactivations during pregnancy than in those with persistent remission [OR 6.9, 95% confidence interval (CI) 1.51-31.28]. Finally, we found that the chances of breastfeeding were 66% lower in patients with IBD than in controls (OR 0.44, 95% CI 0.22-0.91).

Conclusion: Our study underlines the negative impact of IBD on women's reproductive life, supporting the need for proactive preconception counseling.

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炎症性肠病对妇女生育生活的影响：一项基于问卷的研究。

背景：炎症性肠病（IBD）的发病高峰期在人一生的第二至第四个十年之间，并可能影响女性的生殖生活：我们的研究旨在评估 IBD 对女性患者生殖生活的影响：设计：横断面研究：方法：招募在本院 IBD 病房接受随访的 IBD 女性患者和一组健康对照组。结果：研究共纳入 457 名女性，其中有 3 名女性患有 IBD：研究对象包括 457 名女性（其中 228 名患有 IBD）和 229 名年龄匹配的健康对照组。在使用避孕药具、不孕症和子宫内膜异位症方面没有发现差异。IBD患者自然流产和自愿流产的风险明显高于健康对照组[几率比（OR）分别为2和3.62]。在 IBD 患者中，妊娠期疾病再发的患者发生产科并发症的风险比持续缓解的患者高出六倍多[OR 6.9，95% 置信区间（CI）1.51-31.28]。最后，我们发现 IBD 患者母乳喂养的几率比对照组低 66%（OR 0.44，95% CI 0.22-0.91）：我们的研究强调了 IBD 对女性生育生活的负面影响，从而支持了积极进行孕前咨询的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic Advances in Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

6.70

自引率

2.40%

发文量

103

审稿时长

15 weeks

期刊介绍： Therapeutic Advances in Gastroenterology is an open access journal which delivers the highest quality peer-reviewed original research articles, reviews, and scholarly comment on pioneering efforts and innovative studies in the medical treatment of gastrointestinal and hepatic disorders. The journal has a strong clinical and pharmacological focus and is aimed at an international audience of clinicians and researchers in gastroenterology and related disciplines, providing an online forum for rapid dissemination of recent research and perspectives in this area. The editors welcome original research articles across all areas of gastroenterology and hepatology. The journal publishes original research articles and review articles primarily. Original research manuscripts may include laboratory, animal or human/clinical studies – all phases. Letters to the Editor and Case Reports will also be considered.