The interplay between the tumor microenvironment and tumor-derived small extracellular vesicles in cancer development and therapeutic response.

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-12-31 Epub Date: 2024-05-20 DOI:10.1080/15384047.2024.2356831

Xuanyu Guo, Jiajun Song, Miao Liu, Xinyi Ou, Yongcan Guo

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引用次数: 0

Abstract

The tumor microenvironment (TME) plays an essential role in tumor cell survival by profoundly influencing their proliferation, metastasis, immune evasion, and resistance to treatment. Extracellular vesicles (EVs) are small particles released by all cell types and often reflect the state of their parental cells and modulate other cells' functions through the various cargo they transport. Tumor-derived small EVs (TDSEVs) can transport specific proteins, nucleic acids and lipids tailored to propagate tumor signals and establish a favorable TME. Thus, the TME's biological characteristics can affect TDSEV heterogeneity, and this interplay can amplify tumor growth, dissemination, and resistance to therapy. This review discusses the interplay between TME and TDSEVs based on their biological characteristics and summarizes strategies for targeting cancer cells. Additionally, it reviews the current issues and challenges in this field to offer fresh insights into comprehending tumor development mechanisms and exploring innovative clinical applications.

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肿瘤微环境与肿瘤衍生小细胞外囊泡在癌症发展和治疗反应中的相互作用。

肿瘤微环境（TME）对肿瘤细胞的增殖、转移、免疫逃避和抗药性有着深远的影响，在肿瘤细胞的生存过程中扮演着至关重要的角色。细胞外囊泡（EVs）是所有类型细胞释放的小颗粒，通常反映其母细胞的状态，并通过其运输的各种货物调节其他细胞的功能。肿瘤源性小囊泡（TDSEVs）可以运输特定的蛋白质、核酸和脂质，以传播肿瘤信号并建立有利的肿瘤组织生长环境。因此，TME 的生物特性会影响 TDSEV 的异质性，这种相互作用会扩大肿瘤的生长、扩散和抗药性。本综述根据 TME 和 TDSEV 的生物特性讨论了它们之间的相互作用，并总结了针对癌细胞的策略。此外，它还回顾了这一领域目前存在的问题和挑战，为理解肿瘤发生机制和探索创新性临床应用提供新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.