The emerging roles and therapeutic implications of immunosenescence-mediated inflammaging in age-related hearing loss.

IF 1.5 Q4 CELL BIOLOGY

American journal of stem cells Pub Date : 2024-04-25 eCollection Date: 2024-01-01 DOI:10.62347/DTAP3592

Ke Qiu, Minzi Mao, Wendu Pang, Di Deng, Jianjun Ren, Yu Zhao

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Abstract

Age-related hearing loss (ARHL) represents one of the most prevalent chronic sensory deficits experienced by the elderly, significantly diminishing their quality of life and correlating with various medical and psychological morbidities. This condition arises from the cumulative effects of aging on the auditory system, implicating intricate interactions between genetic predispositions and environmental factors. Aging entails a progressive decline in immune system functionality, termed immunosenescence, leading to a chronic low-grade inflammation known as inflammaging. This phenomenon potentially serves as a common mechanism underlying ARHL and other age-related pathologies. Recent research suggests that rejuvenating immunosenescence could mitigate inflammaging and ameliorate age-related functional declines, offering promising insights into anti-aging therapies. Consequently, this review endeavors to elucidate the role of immunosenescence-mediated inflammaging in ARHL progression and discuss its therapeutic implications.

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免疫衰老介导的炎症在老年性听力损失中的新作用和治疗意义。

老年性听力损失（ARHL）是老年人最常见的慢性感官障碍之一，严重降低了他们的生活质量，并与各种医疗和心理疾病相关。这种病症是由于衰老对听觉系统的累积性影响造成的，牵涉到遗传倾向和环境因素之间错综复杂的相互作用。衰老会导致免疫系统功能逐渐衰退，即所谓的免疫衰老，从而导致慢性低度炎症，即所谓的炎症老化。这种现象可能是导致 ARHL 和其他与年龄有关的病症的共同机制。最近的研究表明，使免疫衰老年轻化可减轻炎症反应并改善与年龄相关的功能衰退，从而为抗衰老疗法提供有前景的见解。因此，本综述试图阐明免疫衰老介导的炎症在 ARHL 进展中的作用，并讨论其治疗意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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American journal of stem cells CELL BIOLOGY-

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