{"title":"Starch-supported cuprous iodide nanoparticles catalysed C–C bond cleavage: use of carbon-based leaving groups for bisindolylmethane synthesis","authors":"Muthiah Suresh, Raj Bahadur Singh, Sadhana Katlakunta, Snigdha Rani Patra, Yogesh Bhaskar Singh Tanwer, Sadhucharan Mallick, Sabyasachi Bhunia, Debjit Das","doi":"10.1007/s00706-024-03215-2","DOIUrl":null,"url":null,"abstract":"<p>A starch-supported cuprous iodide nanoparticles (CuI-NPs@starch) catalysed C–C bond cleaving reaction involving carbon-based leaving groups like malononitrile, ethyl cyanoacetate, acetylacetone, and Meldrum’s acid has been developed under moisture and air insensitive conditions. This competent C–C bond cleavage reaction is studied in detail as an attractive alternative method to synthesize biologically relevant bisindolylmethanes in moderate to good yields. The CuI-NPs@starch are synthesized in aqueous medium and characterized by X-ray powder diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy studies.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>","PeriodicalId":19011,"journal":{"name":"Monatshefte für Chemie / Chemical Monthly","volume":"29 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Monatshefte für Chemie / Chemical Monthly","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s00706-024-03215-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A starch-supported cuprous iodide nanoparticles (CuI-NPs@starch) catalysed C–C bond cleaving reaction involving carbon-based leaving groups like malononitrile, ethyl cyanoacetate, acetylacetone, and Meldrum’s acid has been developed under moisture and air insensitive conditions. This competent C–C bond cleavage reaction is studied in detail as an attractive alternative method to synthesize biologically relevant bisindolylmethanes in moderate to good yields. The CuI-NPs@starch are synthesized in aqueous medium and characterized by X-ray powder diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy studies.
在对湿度和空气不敏感的条件下，开发了一种淀粉支撑的碘化亚铜纳米粒子（CuI-NPs@淀粉）催化的 C-C 键裂解反应，该反应涉及丙二腈、氰乙酸乙酯、乙酰丙酮和梅尔德鲁姆酸等碳基离去基团。我们详细研究了这种有效的 C-C 键裂解反应，将其作为一种有吸引力的替代方法，以中等至较高的产率合成与生物相关的双吲哚甲烷。CuI-NPs@starch 是在水介质中合成的，并通过 X 射线粉末衍射、扫描电子显微镜、能量色散 X 射线光谱研究对其进行了表征。
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