Mechanical characterisation of polylactic acid-alendronate bioscrew in different concentrations of glutaraldehyde

IF 0.5 Q4 EDUCATION, SCIENTIFIC DISCIPLINES

Pharmacy Education Pub Date : 2024-05-01 DOI:10.46542/pe.2024.243.101104

Samirah, Nadea Kalila, A. S. Budiatin, Dinda Monika, Nusantara Ratri, Ani Nurul Fauziyah, T. Aryani, Dewi Wara, Alendronate Bioscrew, Glutaraldehyde Human

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引用次数: 0

Abstract

Background: Bioscrew is a developing innovation as a substitute to avoid re-surgery for screw removal; one of the bioscrew materials is polylactic acid (PLA). Alendronate plays a role in reducing osteoclastic activity, causing a decrease in osteoclast-mediated bone resorption, thereby accelerating the process of bone union. Objective: This study determines adding various glutaraldehyde concentrations to the bioscrew mechanical characteristics. Method: This study used the PLA bioscrew immersed into bovine hydroxyapatite (BHA)-gelatin (GEL)-alendronate (ALE) solution, then added with 0% (F1), 1% (F2), and 1,5% (F3) glutaraldehyde (GTA) as cross-link agent. Result: The pore diameter for F1, F2, and F3 were: 38.90±15.34; 29.01±8.94; and 30.58±7.40 μm, respectively. The flexural strength for F1, F2, and F3 were: 1.00±0.22, 1.18±0.13, and 1.11±0.16 MPa, respectively. The pull-out strength for F1, F2, and F3 were: 4.88 ± 0.79; 7.87 ± 0.24; and 7.65±1.02 N, respectively. The degradation rate for F1, F2, and F3 were: 14.40±2.08; 3.81±0.67; and 4.97±0.58 %, respectively. This study has found that glutaraldehyde concentrations significantly affect pull-out strength and degradation rate. The highest mechanical strength and slowest degradation rate for % weight loss was F2. Conclusion: Adding glutaraldehyde may enhance the mechanical characteristics of the bioscrew.

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聚乳酸-阿仑膦酸盐生物螺旋在不同浓度戊二醛中的机械特性分析

背景：生物螺钉是一种不断发展的创新技术，它可以替代螺钉取出手术，避免再次手术；生物螺钉材料之一是聚乳酸（PLA）。阿仑膦酸盐具有降低破骨细胞活性的作用，可减少破骨细胞介导的骨吸收，从而加速骨结合过程：本研究确定了添加不同浓度戊二醛对生物螺旋机械特性的影响：本研究将聚乳酸生物螺杆浸入牛羟基磷灰石（BHA）-明胶（GEL）-阿仑膦酸盐（ALE）溶液中，然后添加 0%（F1）、1%（F2）和 1.5%（F3）戊二醛（GTA）作为交联剂：结果：F1、F2 和 F3 的孔径分别为 38.90±15.34；38.90±15.34；38.90±15.34：分别为 38.90±15.34、29.01±8.94 和 30.58±7.40 μm。F1、F2 和 F3 的抗折强度分别为：1.00±0.22、1.00±0.22 和 1.00±0.22：分别为 1.00±0.22、1.18±0.13 和 1.11±0.16 MPa。F1、F2 和 F3 的抗拉强度分别为：4.88 ± 0.79；4.88 ± 0.79；4.88 ± 0.79：分别为 4.88 ± 0.79、7.87 ± 0.24 和 7.65±1.02 N。F1、F2 和 F3 的降解率分别为：14.40±2.08 N；7.87±0.24 N；7.65±1.02 N：分别为：14.40±2.08%；3.81±0.67%；4.97±0.58%。这项研究发现，戊二醛浓度对拔出强度和降解率有显著影响。F2 的机械强度最高，失重率降解速度最慢：结论：添加戊二醛可增强生物螺旋的机械特性。

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来源期刊

Pharmacy Education EDUCATION, SCIENTIFIC DISCIPLINES-

CiteScore

0.80

自引率

20.00%

发文量

174

期刊介绍： Pharmacy Education journal provides a research, development and evaluation forum for communication between academic teachers, researchers and practitioners in professional and pharmacy education, with an emphasis on new and established teaching and learning methods, new curriculum and syllabus directions, educational outcomes, guidance on structuring courses and assessing achievement, and workforce development. It is a peer-reviewed online open access platform for the dissemination of new ideas in professional pharmacy education and workforce development. Pharmacy Education supports Open Access (OA): free, unrestricted online access to research outputs. Readers are able to access the Journal and individual published articles for free - there are no subscription fees or ''pay per view'' charges. Authors wishing to publish their work in Pharmacy Education do so without incurring any financial costs.