Mechanical characterisation of polylactic acid-alendronate bioscrew in different concentrations of glutaraldehyde

Pub Date : 2024-05-01 DOI:10.46542/pe.2024.243.101104

Samirah, Nadea Kalila, A. S. Budiatin, Dinda Monika, Nusantara Ratri, Ani Nurul Fauziyah, T. Aryani, Dewi Wara, Alendronate Bioscrew, Glutaraldehyde Human

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Abstract

Background: Bioscrew is a developing innovation as a substitute to avoid re-surgery for screw removal; one of the bioscrew materials is polylactic acid (PLA). Alendronate plays a role in reducing osteoclastic activity, causing a decrease in osteoclast-mediated bone resorption, thereby accelerating the process of bone union. Objective: This study determines adding various glutaraldehyde concentrations to the bioscrew mechanical characteristics. Method: This study used the PLA bioscrew immersed into bovine hydroxyapatite (BHA)-gelatin (GEL)-alendronate (ALE) solution, then added with 0% (F1), 1% (F2), and 1,5% (F3) glutaraldehyde (GTA) as cross-link agent. Result: The pore diameter for F1, F2, and F3 were: 38.90±15.34; 29.01±8.94; and 30.58±7.40 μm, respectively. The flexural strength for F1, F2, and F3 were: 1.00±0.22, 1.18±0.13, and 1.11±0.16 MPa, respectively. The pull-out strength for F1, F2, and F3 were: 4.88 ± 0.79; 7.87 ± 0.24; and 7.65±1.02 N, respectively. The degradation rate for F1, F2, and F3 were: 14.40±2.08; 3.81±0.67; and 4.97±0.58 %, respectively. This study has found that glutaraldehyde concentrations significantly affect pull-out strength and degradation rate. The highest mechanical strength and slowest degradation rate for % weight loss was F2. Conclusion: Adding glutaraldehyde may enhance the mechanical characteristics of the bioscrew.

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聚乳酸-阿仑膦酸盐生物螺旋在不同浓度戊二醛中的机械特性分析

背景：生物螺钉是一种不断发展的创新技术，它可以替代螺钉取出手术，避免再次手术；生物螺钉材料之一是聚乳酸（PLA）。阿仑膦酸盐具有降低破骨细胞活性的作用，可减少破骨细胞介导的骨吸收，从而加速骨结合过程：本研究确定了添加不同浓度戊二醛对生物螺旋机械特性的影响：本研究将聚乳酸生物螺杆浸入牛羟基磷灰石（BHA）-明胶（GEL）-阿仑膦酸盐（ALE）溶液中，然后添加 0%（F1）、1%（F2）和 1.5%（F3）戊二醛（GTA）作为交联剂：结果：F1、F2 和 F3 的孔径分别为 38.90±15.34；38.90±15.34；38.90±15.34：分别为 38.90±15.34、29.01±8.94 和 30.58±7.40 μm。F1、F2 和 F3 的抗折强度分别为：1.00±0.22、1.00±0.22 和 1.00±0.22：分别为 1.00±0.22、1.18±0.13 和 1.11±0.16 MPa。F1、F2 和 F3 的抗拉强度分别为：4.88 ± 0.79；4.88 ± 0.79；4.88 ± 0.79：分别为 4.88 ± 0.79、7.87 ± 0.24 和 7.65±1.02 N。F1、F2 和 F3 的降解率分别为：14.40±2.08 N；7.87±0.24 N；7.65±1.02 N：分别为：14.40±2.08%；3.81±0.67%；4.97±0.58%。这项研究发现，戊二醛浓度对拔出强度和降解率有显著影响。F2 的机械强度最高，失重率降解速度最慢：结论：添加戊二醛可增强生物螺旋的机械特性。

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