NAFLD PATHOGENESIS AND CLINICAL ASSOCIATIONS WITH CARDIOVASCULAR DISEASES

Abstract

Non-alcoholic fatty liver disease (NAFLD) is an expan­ding issue in prevention and treatment. The central patho­logical processes of NAFLD comprise pathological lipid accumulation resulting in insulin resistance, oxidative stress, mitochondrial dysfunction, inflammation, and endoplasmic reticulum stress. NAFLD is firmly associ­ated with a raised risk of major cardiovascular events. This literature review seeks to overview the pathophy­siological mechanisms of NAFLD and provide proof of a connection between NAFLD and an augmented risk of cardiovascular complications.