The Combination of Systemic Immune-Inflammation Index and Serum Procalcitonin has High Auxiliary Predictive Value for Short-Term Adverse Prognosis in Septic Shock Patients

IF 1.2 4区 医学 Q3 EMERGENCY MEDICINE
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引用次数: 0

Abstract

Background

Septic shock is the most serious complication of sepsis, with more secure and efficient biomarkers urgently needed. Systemic immune-inflammation index (SII) and serum procalcitonin (PCT) show involvement in predicting septic shock prognosis.

Objective

Herein, we explored the clinical value of the SII-PCT combination in the short-term prognosis of septic shock patients.

Methods

Totally 200 septic shock patients were analyzed retrospectively and allocated into the survival and death groups upon 28-day in-hospital outcomes. Correlations of SII, PCT, acute physiology and chronic health evaluation II (APACHE II)/sepsis-related organ failure assessment (SOFA) scores, C-reactive protein (CRP), and serum creatinine (Scr) were analyzed using Spearman. The influencing factors of SII and serum PCT for short-term poor prognosis were analyzed using logistic multivariate regression model. The auxiliary predictive value of SII, PCT, and their combination for short-term adverse septic shock prognosis was evaluated by the receiver operating characteristic curve. Differences in the area under the curve (AUC) were compared using MedCalc.

Results

The death group had higher APACHE II/SOFA scores, LYM, CRP, Scr, SII, and PCT levels than the survival group. SII and PCT were positively correlated with APACHE II and SOFA scores, LYM, CRP, and Scr, and were independent risk factors influencing the adverse septic shock prognosis. The AUC of the SII-PCT combination in predicting short-term adverse septic shock prognosis was 0.893 (0.841-0.932), with 76.12% sensitivity and 87.97% specificity, with the combination showing a higher AUC than SII/PCT alone.

Conclusions

The SII-PCT combination helps predict the adverse prognosis of septic shock patients.

全身免疫炎症指数和血清降钙素原的组合对脓毒性休克患者的短期不良预后具有较高的辅助预测价值
背景脓毒性休克是脓毒症最严重的并发症,迫切需要更安全有效的生物标志物。本文探讨了 SII-PCT 组合在脓毒性休克患者短期预后中的临床价值。方法回顾性分析了 200 例脓毒性休克患者,并根据 28 天的住院结果将其分为生存组和死亡组。用 Spearman 分析了 SII、PCT、急性生理学和慢性健康评估 II(APACHE II)/脓毒症相关器官衰竭评估(SOFA)评分、C 反应蛋白(CRP)和血清肌酐(Scr)的相关性。采用逻辑多元回归模型分析了 SII 和血清 PCT 对短期不良预后的影响因素。通过接收者操作特征曲线评估了 SⅡ、PCT 及其组合对短期不良脓毒性休克预后的辅助预测价值。结果 死亡组的 APACHE II/SOFA 评分、LYM、CRP、Scr、SII 和 PCT 水平均高于生存组。SII和PCT与APACHE II和SOFA评分、LYM、CRP和Scr呈正相关,是影响脓毒性休克不良预后的独立危险因素。SII-PCT组合预测脓毒性休克短期不良预后的AUC为0.893(0.841-0.932),敏感性为76.12%,特异性为87.97%,组合的AUC高于单独使用SII/PCT的AUC。
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来源期刊
Journal of Emergency Medicine
Journal of Emergency Medicine 医学-急救医学
CiteScore
2.40
自引率
6.70%
发文量
339
审稿时长
2-4 weeks
期刊介绍: The Journal of Emergency Medicine is an international, peer-reviewed publication featuring original contributions of interest to both the academic and practicing emergency physician. JEM, published monthly, contains research papers and clinical studies as well as articles focusing on the training of emergency physicians and on the practice of emergency medicine. The Journal features the following sections: • Original Contributions • Clinical Communications: Pediatric, Adult, OB/GYN • Selected Topics: Toxicology, Prehospital Care, The Difficult Airway, Aeromedical Emergencies, Disaster Medicine, Cardiology Commentary, Emergency Radiology, Critical Care, Sports Medicine, Wound Care • Techniques and Procedures • Technical Tips • Clinical Laboratory in Emergency Medicine • Pharmacology in Emergency Medicine • Case Presentations of the Harvard Emergency Medicine Residency • Visual Diagnosis in Emergency Medicine • Medical Classics • Emergency Forum • Editorial(s) • Letters to the Editor • Education • Administration of Emergency Medicine • International Emergency Medicine • Computers in Emergency Medicine • Violence: Recognition, Management, and Prevention • Ethics • Humanities and Medicine • American Academy of Emergency Medicine • AAEM Medical Student Forum • Book and Other Media Reviews • Calendar of Events • Abstracts • Trauma Reports • Ultrasound in Emergency Medicine
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