Rank-based sequential feature selection for high-dimensional accelerated failure time models with main and interaction effects

IF 1.5 3区数学 Q3 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS

Computational Statistics & Data Analysis Pub Date : 2024-05-13 DOI:10.1016/j.csda.2024.107978

Ke Yu, Shan Luo

引用次数: 0

Abstract

High-dimensional accelerated failure time (AFT) models are commonly used regression models in survival analysis. Feature selection problem in high-dimensional AFT models is addressed, considering scenarios involving solely main effects or encompassing both main and interaction effects. A rank-based sequential feature selection (RankSFS) method is proposed, the selection consistency is established and illustrated by comparing it with existing methods through extensive numerical simulations. The results show that RankSFS achieves a higher Positive Discovery Rate (PDR) and lower False Discovery Rate (FDR). Additionally, RankSFS is applied to analyze the data on Breast Cancer Relapse. With a remarkable short computational time, RankSFS successfully identifies two crucial genes.

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基于等级的序列特征选择，用于具有主效应和交互效应的高维加速故障时间模型

高维加速失效时间（AFT）模型是生存分析中常用的回归模型。考虑到只涉及主效应或同时包含主效应和交互效应的情况，本文探讨了高维 AFT 模型中的特征选择问题。本文提出了一种基于秩的序列特征选择（RankSFS）方法，并通过大量数值模拟将其与现有方法进行比较，从而确定了选择的一致性。结果表明，RankSFS 实现了更高的正发现率（PDR）和更低的误发现率（FDR）。此外，RankSFS 还被用于分析乳腺癌复发数据。在极短的计算时间内，RankSFS 成功识别了两个关键基因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Computational Statistics & Data Analysis 数学-计算机：跨学科应用

CiteScore

3.70

自引率

5.60%

发文量

167

审稿时长

60 days

期刊介绍： Computational Statistics and Data Analysis (CSDA), an Official Publication of the network Computational and Methodological Statistics (CMStatistics) and of the International Association for Statistical Computing (IASC), is an international journal dedicated to the dissemination of methodological research and applications in the areas of computational statistics and data analysis. The journal consists of four refereed sections which are divided into the following subject areas: I) Computational Statistics - Manuscripts dealing with: 1) the explicit impact of computers on statistical methodology (e.g., Bayesian computing, bioinformatics,computer graphics, computer intensive inferential methods, data exploration, data mining, expert systems, heuristics, knowledge based systems, machine learning, neural networks, numerical and optimization methods, parallel computing, statistical databases, statistical systems), and 2) the development, evaluation and validation of statistical software and algorithms. Software and algorithms can be submitted with manuscripts and will be stored together with the online article. II) Statistical Methodology for Data Analysis - Manuscripts dealing with novel and original data analytical strategies and methodologies applied in biostatistics (design and analytic methods for clinical trials, epidemiological studies, statistical genetics, or genetic/environmental interactions), chemometrics, classification, data exploration, density estimation, design of experiments, environmetrics, education, image analysis, marketing, model free data exploration, pattern recognition, psychometrics, statistical physics, image processing, robust procedures. [...] III) Special Applications - [...] IV) Annals of Statistical Data Science [...]