PROGNOSTIC SIGNIFICANCE OF SERUM CREATINE PHOSPHOKINASE LEVELS IN ORGANOPHOSPHOROUS POISONING : AN OBSERVATIONAL STUDY IN A TERTIARY CARE HOSPITAL

Abstract

Background:organophosphorous poisoning is the major cause of mortality and morbidity in developing countries like india. It is the most commonly used insecticide in India and easily available. Erythrocyte cholinesterase and butyryl cholinesterase are markers for assessing the severity of OPpoisoning, but they are costly and not available at all centers. This study was done to assess and nd out the correlation of CPK levels with severity of OPpoisoning Aims & Objectives :To assess serum creatine phosphokinase (CPK) level in OPpoisoning To nd out the correlation of serum creatine phosphokinase (CPK) level With the severity of OPpoisoning Materials And Methods: AHospital-based cross-sectional study was conducted in the Department of General Medicine, Santhiram medical college, and the general hospital for six months. A total of 100 cases with OP poisoning admitted to wards &ICU who satisfy the inclusion criteria were taken in to study. Results: Out of 100 patients 63 % were males and 37 % were females. Majority were in age group 19 -30 years. Methyl parathion was the most commonly used compound. Most of the cases presented with mild op poisoning. Serial measurement of serum CPK levels showed signicant correlation with the severity of acute OPpoisoning patients. Conclusion: High initial serum CPK levels is associated with severe degree of poisoning and is associated with complications and mortality. CPK may be considered as a prognostic marker of OPC intoxication since it enables the early recognition of severity and also helps to identify those at risk of developing the delayed complications of OPC poisoning