{"title":"Do plasma-rich protein injections have a role in orthopaedics? A systematic review and meta-analysis of the randomized control trials","authors":"Marjan Raad, Priya Sekhon, Alastair Robertson","doi":"10.1016/j.mporth.2024.03.006","DOIUrl":null,"url":null,"abstract":"<div><p>We evaluated the effectiveness of plasma-rich protein injections (PRP) in terms of pain, patient-reported outcomes and function in degenerative joint disease and tendinopathy. The search strategies were ran in Ovid Medline and Ovid Embase in October 2023 by a clinical librarian. Results were limited to the last 10 years. The search terms used were ‘platelet rich plasma’ and ‘orthopaedics’. After screening and the eligibility process this resulted in 18 randomized control trials (RCTs). We analysed 18 level 1 RCTs in regard to gluteal tendinopathy, hip osteoarthritis, patella tendinopathy, knee osteoarthritis, Achilles tendinopathy, plantar fasciitis, rotator cuff tendinopathy and elbow tendinopathy. Further research, such as meta-analyses and double-blinded trials with more patients, longer follow-up and with a placebo group, is needed to better elucidate the safety and efficacy of PRP injections.</p></div>","PeriodicalId":39547,"journal":{"name":"Orthopaedics and Trauma","volume":"38 3","pages":"Pages 152-155"},"PeriodicalIF":0.0000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Orthopaedics and Trauma","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1877132724000459","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
We evaluated the effectiveness of plasma-rich protein injections (PRP) in terms of pain, patient-reported outcomes and function in degenerative joint disease and tendinopathy. The search strategies were ran in Ovid Medline and Ovid Embase in October 2023 by a clinical librarian. Results were limited to the last 10 years. The search terms used were ‘platelet rich plasma’ and ‘orthopaedics’. After screening and the eligibility process this resulted in 18 randomized control trials (RCTs). We analysed 18 level 1 RCTs in regard to gluteal tendinopathy, hip osteoarthritis, patella tendinopathy, knee osteoarthritis, Achilles tendinopathy, plantar fasciitis, rotator cuff tendinopathy and elbow tendinopathy. Further research, such as meta-analyses and double-blinded trials with more patients, longer follow-up and with a placebo group, is needed to better elucidate the safety and efficacy of PRP injections.
期刊介绍：
Orthopaedics and Trauma presents a unique collection of International review articles summarizing the current state of knowledge and research in orthopaedics. Each issue focuses on a specific topic, discussed in depth in a mini-symposium; other articles cover the areas of basic science, medicine, children/adults, trauma, imaging and historical review. There is also an annotation, self-assessment questions and a second opinion section. In this way the entire postgraduate syllabus will be covered in a 4-year cycle.
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