Analysis of efficacy of metformin in pregnant women with Polycystic Ovarian Syndrome (PCOS).

The professional medical journal Pub Date : 2024-05-04 DOI:10.29309/tpmj/2024.31.05.8075

Sohail Anjum, Sarah Hafeez Malik, Nighat Nadeem, Sohail Bashir Sulehria

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Abstract

Objective: (1)To analyze of efficacy of metformin in pregnant women with POCS regarding occurrence of gestational diabetes mellitus (2) To analyze parity distribution for efficacy of metformin regarding occurrence of gestational diabetes mellitus in pregnant women with POCS. Study Design: Descriptive Cases Series. Setting: Sheikh Zaid Hospital, Lahore. Period: July 1, 2019 to December 31, 2019. Methods: Till delivery 200 pregnant ladies were followed up to see if they developed GDM or not. A pre-prepared form was used to record metformin efficacy frequency and GDM in pregnant ladies with PCOS. For efficacy and parity (qualitative variables), percentages and frequencies were got calculated using SPSS.16. Results: Thirty two (16%) women got ‘0’ parity. Forty four (22%) got ‘1’parity. Fifty (25%) got ‘2’ parity. Forty two (21%) got ‘3’parity.While thirty two women (16%) got ‘4’ parity. Twenty two (78.57%) was efficacy for nulliparous patients. Thirty three (76.74%) was efficacy for primiparous patients. One hundred nine (84.50%) was efficacy for multiparous patients. Insignificant difference was noted as p was more than 0.05. In one hundred sixty six (83%) women metformin efficacy got achieved. Conclusion: Multiparous patients with PCOS showed relatively more efficacy (84.50%) of metformin against gestational diabetes mellitus while twenty five percent pregnant women with PCOS with a thorough use of metformin delivered two live neonates.

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二甲双胍对多囊卵巢综合征（PCOS）孕妇的疗效分析。

目的：（1）分析二甲双胍对 POCS 孕妇妊娠糖尿病发生的疗效（2）分析二甲双胍对 POCS 孕妇妊娠糖尿病发生的疗效的奇偶分布。研究设计：描述性病例系列。研究地点拉合尔谢赫扎伊德医院。时间： 2019 年 7 月 1 日至 12 月 31 日2019 年 7 月 1 日至 2019 年 12 月 31 日。方法对 200 名孕妇进行随访，观察她们是否出现 GDM，直至分娩。使用事先准备好的表格记录二甲双胍的疗效频率和多囊卵巢综合征孕妇的 GDM。使用 SPSS.16 计算疗效和奇偶数（定性变量）的百分比和频率。结果32（16%）名妇女的奇偶性为 "0"。44名妇女（22%）的奇偶数为 "1"。50（25%）人的奇偶数为 "2"。有 42 名妇女（21%）获得了 "3 "等位，有 32 名妇女（16%）获得了 "4 "等位。22例（78.57%）为无阴道患者。初产妇疗效为 33 例（76.74%）。多胎患者的疗效为 109 例（84.50%）。P 值大于 0.05 时，差异不显著。二甲双胍对 166 名（83%）妇女有效。结论多囊卵巢综合征的多产妇使用二甲双胍治疗妊娠糖尿病的疗效相对较好（84.50%），而 25% 的多囊卵巢综合征孕妇在彻底使用二甲双胍后产下了两个活产新生儿。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The professional medical journal

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