Clinical protocol for the care of ophidiotoxicosis in canines in Colombia

Zairat Yiseth Herrera-Dalel, María Paula Montoya-Forero, Daniel Zambrano-Lugo, L. N. Pedraza-Castillo, D. Jaramillo-Hernández
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Abstract

Every year, according to the World Health Organization, nearly 5,000,000 million accidents due to snake bites are reported worldwide, of which it is estimated that 33.3% to 50% of cases present as poisoning. Ophidic accidents that include ophidiotoxicosis have care protocols of therapy with antivenom serums, which vary according to the genus and species of the snake. Although in Colombia there are protocols for the care of ophidiotoxicosis in humans described by health entities, the canine clinic lacks this information. The aim of this systematic review is to build a medical protocol for ophidiotoxicosis in canines  based on information reported in Colombia or tropical countries with which similar venomous snakes are shared. For this action, the PRISMA protocol was used; in total, 57 articles and 10 official documents on protocols for the care of ophidic accidents in humans were reviewed, which allowed the possible to classify snakebite accidents in group 1 (Bothrops, Lachesis and Crotalus accidents) and group 2 (Micrurus accident), also establish a medical protocol for ophidiotoxicosis in each of the groups indicated in canines, depending on the severity of the clinical and paraclinical condition. In conclusion, the clinical and paraclinical signs of the canine, vasculotoxic or neurotoxic, allow us to identify the group to which the aggressor snake belongs (group 1 or group 2, respectively), and their severity guides the selection and dosage of antivenom therapy specific for the clinical management of ophidiotoxicosis in canines.
哥伦比亚犬类蚜虫中毒临床治疗方案
根据世界卫生组织的报告,全世界每年发生近 50 亿起蛇咬伤事故,其中估计有 33.3%至 50%的病例表现为中毒。包括蛇毒中毒在内的蛇咬伤事故都有抗蛇毒血清治疗方案,这些方案因蛇的属种而异。虽然哥伦比亚的医疗机构制定了治疗人类蚜虫中毒的方案,但犬科诊所却缺乏这方面的信息。本系统综述的目的是根据哥伦比亚或与哥伦比亚有类似毒蛇的热带国家报告的信息,制定犬类蚜虫中毒的医疗方案。为此,我们采用了 PRISMA 协议;总共审查了 57 篇文章和 10 份关于人类蛇毒中毒事故护理协议的官方文件,从而可以将蛇咬伤事故分为第 1 组(Bothrops、Lachesis 和 Crotalus 事故)和第 2 组(Micrurus 事故),并根据临床和准临床状况的严重程度,为每一组中的犬类制定蛇毒中毒医疗协议。总之,犬类的临床和副临床症状(血管毒性或神经毒性)使我们能够确定侵害蛇所属的组别(分别为第 1 组或第 2 组),这些症状的严重程度指导着抗蛇毒血清疗法的选择和剂量,这些抗蛇毒血清疗法专门用于犬类的蛇毒中毒临床治疗。
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