Assessment of the CO2 water bath therapy effectiveness on diabetic foot ulcers through VEGF and TNF-α levels

Ghazwan Riyad Abdulhamza, Najeeb Hassan Mohammed
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Abstract

Vasculopathy is typically seen in diabetic patients, and can lead to foot ulcerations. Carbon dioxide (CO2) therapy was found to improve chronic wound healing in patients with vascular impairment. This type of therapy refers to the transcutaneous and subcutaneous application of CO2 as well as CO2 water baths for therapeutic purposes. In the method used herein, artificial CO2-containing water for foot bathing was generated by dissolving Carbothera® (MRE-SPA-MD; Mitsubishi Rayon Engineering, Tokyo, Japan) and generating CO2 (free CO2 concentration: 1,000–1,200 mg/L; pH 4.6). The foot of each patient was immersed in CO2-enriched water (depth of 20–30 cm, 37–38°C, 30-min duration) three times per week, for the next three months. Dramatic clinical improvement was observed in the CO2 water bath therapy group before and after the treatment, while both the blood levels of the vascular endothelial growth factor and of the tumour necrosis factor-alpha in these patients exhibited significant changes. The advantages of this method are the absence of pain and the protection against infection, while the improved angiogenesis and oxygena¬tion can result in healing of the chronic wound.
通过血管内皮生长因子和 TNF-α 水平评估二氧化碳水浴疗法对糖尿病足溃疡的疗效
血管病变通常见于糖尿病患者,可导致足部溃疡。研究发现,二氧化碳(CO2)疗法可改善血管损伤患者的慢性伤口愈合。这种疗法指的是经皮和皮下施用二氧化碳以及用于治疗目的的二氧化碳水浴。本文所采用的方法是通过溶解 Carbothera® (MRE-SPA-MD;三菱丽阳工程公司,日本东京)并产生二氧化碳(游离二氧化碳浓度:1,000-1,200 毫克/升;pH 值 4.6)来生成足浴用的人工含二氧化碳水。在接下来的三个月中,每周三次将每位患者的足部浸泡在富含二氧化碳的水中(深度 20-30 厘米,温度 37-38°C,持续时间 30 分钟)。二氧化碳水浴疗法组患者在治疗前后的临床症状均有明显改善,而这些患者血液中的血管内皮生长因子和肿瘤坏死因子-α的水平均有显著变化。这种方法的优点是无痛苦、抗感染,同时血管生成和氧合作用的改善可使慢性伤口愈合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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