Histopathological Evaluation of Pulp Reaction to Potassium Nitrate in Polycarboxylate Cement Compared with Mineral Trioxide Aggregate in Immature Dogs' Teeth

Moustafa Mohammed Sayed, Khaled Radad, Xiaohui Rausch-Fan, A. Elheeny
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Abstract

Objective The vitality of the pulp and the formation of new dentin are important for the success of direct pulp capping (DPC). Accordingly, the present study aims to histologically evaluate the pulp reaction to potassium nitrate in polycarboxylate cement (KNO3/PCA) compared with mineral trioxide aggregate (MTA) in immature dogs' teeth. DPC was done on 48 teeth in three dogs (16 for each dog, 8 for each material). Materials and Methods After 2, 3, and 4 months, a dog was euthanized at each time interval. Capped teeth were extracted, demineralized, and processed for histopathological examination based on the presence of inflammation, granulation tissue, hard tissue, and dentin bridge. Results Inflammatory changes were absent in both MTA- and KNO3/PCA-capped teeth at the three time intervals. The incidence of granulation tissue formation was higher in MTA- (75, 87.5, and 87.5%) than in KNO3/PCA-capped teeth (62.5, 75, and 75%) after 2, 3, and 4 months after DPC, respectively. Hard tissue was seen after 3 months of DPC with both MTA and KNO3/PCA. It was more evident in MTA-capped teeth with an incidence of 75 and 75%, and 12.5 and 25% in teeth capped with KNO3/PCA after 3 and 4 months, respectively. Dentin bridge was only noticed in MTA-capped teeth after 3 and 4 months intervals. Conclusion Taken all together, pulpal responses in the form of granulation and hard tissues, and dentin bridge formation are more evident in MTA-capped teeth than those capped with KNO3/PCA in immature dogs.
组织病理学评估未成熟犬牙齿对聚羧酸盐水泥中硝酸钾与三氧化二铝矿物骨料的牙髓反应的比较
目的 牙髓的活力和新牙本质的形成对直接牙髓覆盖(DPC)的成功非常重要。因此,本研究旨在从组织学角度评估牙髓对硝酸钾聚羧酸盐骨水泥(KNO3/PCA)和三氧化物矿物质骨水泥(MTA)的反应。对三只狗的 48 颗牙齿进行了 DPC(每只狗 16 颗,每种材料 8 颗)。材料和方法 2、3 和 4 个月后,每隔一段时间对一只狗实施安乐死。拔出被盖住的牙齿,进行脱矿处理,并根据是否存在炎症、肉芽组织、硬组织和牙本质桥进行组织病理学检查。结果 在三个时间间隔内,MTA 和 KNO3/PCA 封闭的牙齿均无炎症变化。DPC 2、3 和 4 个月后,MTA-(75%、87.5% 和 87.5%)比 KNO3/PCA 封闭牙齿(62.5%、75% 和 75%)的肉芽组织形成率更高。使用 MTA 和 KNO3/PCA 进行 DPC 3 个月后,均可看到硬组织。硬组织在 MTA 覆层的牙齿中更为明显,3 个月和 4 个月后的发生率分别为 75% 和 75%,在 KNO3/PCA 覆层的牙齿中分别为 12.5% 和 25%。只有在 3 个月和 4 个月后,MTA 封顶的牙齿才会出现牙本质桥。结论 综上所述,在未成熟犬中,MTA 封顶的牙齿比 KNO3/PCA 封顶的牙齿更容易出现肉芽和硬组织形式的牙髓反应以及牙本质桥的形成。
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