Melatonin Modulates Lipid Metabolism and Reduces Cardiovascular Risk in Apolipoprotein E-Deficient Mice Fed a Western Diet

Guillermo Santos-Sánchez, A. I. Álvarez-López, Eduardo Ponce-España, A. Álvarez-Ríos, P. Lardone, A. Carrillo-Vico, Ivan Cruz-Chamorro
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Abstract

Melatonin (MLT), a natural compound found in the animal and vegetable kingdom, participates in several physiological processes. MLT exerts antioxidant and anti-inflammatory activities, among others, but information about its action on lipid metabolism is still scarce. For this reason, mice deficient in apolipoprotein E (ApoE−/−) fed a Western diet (WD) were intragastrically treated with different concentrations of MLT (2 and 9 mg/kg) for 12 weeks. The lipid parameters were quantified, and, since links between cardiovascular risk and immune function and oxidative stress have been established, we also analyzed the population of leukocytes and the oxidative stress status. Although there was no change in the weight of the mice, a significant reduction in low-density lipoprotein cholesterol (LDL-C) was observed in mice treated with the higher concentration of MLT tested in this study. Additionally, an improvement in cardiovascular risk indexes was observed. A reduction in the hepatic total cholesterol (TC) and LDL-C levels was also observed in the treated mice. Finally, a decrease in leukocytes and lymphocytes in particular, as well as an increase in the antioxidant status, were shown in MLT-treated mice. In conclusion, MLT is a promising candidate that could be considered as a possible functional ingredient capable of preventing cardiovascular risk.
褪黑激素调节脂质代谢并降低以西式饮食喂养的载脂蛋白 E 缺乏小鼠的心血管风险
褪黑素(MLT)是一种存在于动物和植物界的天然化合物,参与多种生理过程。褪黑素具有抗氧化和抗炎等活性,但有关其对脂质代谢作用的信息仍然很少。因此,对缺乏载脂蛋白 E(载脂蛋白 E-/-)、以西式饮食(WD)为食的小鼠灌胃不同浓度的 MLT(2 毫克和 9 毫克/千克),持续 12 周。由于心血管风险与免疫功能和氧化应激之间的联系已经确立,我们还分析了白细胞数量和氧化应激状态。虽然小鼠的体重没有变化,但在使用本研究中测试的较高浓度 MLT 的小鼠中观察到低密度脂蛋白胆固醇(LDL-C)显著降低。此外,还观察到心血管风险指数有所改善。接受治疗的小鼠肝脏总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)水平也有所下降。最后,MLT 治疗小鼠的白细胞和淋巴细胞减少,抗氧化能力增强。总之,MLT 是一种很有前景的候选物质,可被视为一种能够预防心血管风险的功能性成分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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