Evaluation of the antioxidant and anti-inflammatory properties of the hydroethanolic extract of the leaves of Blighia sapida KD Koenig

International Journal of Biological and Chemical Sciences Pub Date : 2024-05-09 DOI:10.4314/ijbcs.v18i1.2

Affo Dermane, Warapissime Tayama, P. Kpoyizoun, P. Kola, K. Metowogo, K. Eklu-Gadegbeku

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Abstract

Blighia sapida is widely used in traditional medicine for the treatment of several diseases in Togo. This study aimed to assess the antioxidant and anti-inflammatory properties of Blighia sapida. To this end, a phytochemical screening was carried out, followed by an assessment of DPPH, total antioxidant capacity, ex vivo lipoperoxidation tests on Sprague Dawley rats, and an evaluation of anti- inflammatory activity by the egg albumin denaturation test. The leaves extract scavenged the DPPH free radical with an IC50 of 172 ± 0.577µg/mL and its total antioxidant capacity value was 40.174 ± 0.638 mg Eq AA/g. In the ex vivo lipoperoxidation test on the kidney and liver, the extract showed a significant inhibitory effect. Phytochemical tests revealed the presence of tannins, flavonoids, alkaloids, saponosides, and carbohydrate compounds. The present results showed that Blighia sapida leaves possess antioxidant and anti- inflammatory properties which may be linked to the bioactive compounds they contain, suggesting their use to prevent oxidative and inflammatory processes.

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对 Blighia sapida KD Koenig 叶片水乙醇提取物抗氧化和抗炎特性的评估

多哥的传统医学中广泛使用百里香来治疗多种疾病。本研究旨在评估 Blighia sapida 的抗氧化和抗炎特性。为此，首先进行了植物化学筛选，然后评估了 DPPH、总抗氧化能力、Sprague Dawley 大鼠体内外脂过氧化试验，并通过鸡蛋白蛋白变性试验评估了抗炎活性。叶提取物清除 DPPH 自由基的 IC50 值为 172 ± 0.577µg/mL ，总抗氧化能力值为 40.174 ± 0.638 mg Eq AA/g。在肾脏和肝脏的体内脂过氧化试验中，提取物显示出明显的抑制作用。植物化学测试显示了鞣质、黄酮类、生物碱、皂苷和碳水化合物的存在。本研究结果表明，皂荚叶具有抗氧化和抗炎症的特性，这可能与其所含的生物活性化合物有关，建议将其用于预防氧化和炎症过程。

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来源期刊

International Journal of Biological and Chemical Sciences

CiteScore

0.90

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