Plant protein substitution for animal protein and its association with cardiovascular risk factors and inflammatory biomarkers in elderly men: A substitution analysis

Q3 Medicine

Nutrition and Healthy Aging Pub Date : 2024-05-09 DOI:10.3233/nha-231519

Hanieh Abbasi, Noushin Fahimfar, M. Nazarzadeh, Leila Azadbakht

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引用次数: 0

Abstract

BACKGROUND: Substituting different types of protein intake may be associated with cardiovascular risk factors and inflammatory biomarkers. However, there are few studies conducted on elders and the findings are contradictory. OBJECTIVE: We decided to examine the association of substituting plant protein for animal protein with cardiovascular risk factors and inflammatory biomarkers among elderly men. METHOD: The current cross-sectional study included 357 elderly men chosen from health centres in southern Tehran, Iran. They provide written consent to be included in the study. We used a validated and reliable food frequency questionnaire (FFQ) to assess dietary intake. All biochemical factors like lipid profile, fasting blood sugar (FBS), high sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL6), tumor necrosis factor-α (TNF-α) were measured. Waist circumference (WC) and blood pressure (BP) were also assessed. The substitution analysis by STATA was used to examine the aforementioned association. RESULTS: Substituting animal protein with plant protein had significant beneficial association with WC (OR: –4.28; 95% CI: –8.51, –0.62; Ptrend = 0.047) and LDL/HDL (OR: –0.26; 95% CI: –0.48, –0.05; Ptrend = 0.018). CONCLUSION: In elderly men, substituting animal protein with plant protein had favorable association with some of cardiovascular risk factors including WC and LDL/HDL but there was no significant association for inflammatory biomarkers.

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植物蛋白替代动物蛋白及其与老年男性心血管风险因素和炎症生物标志物的关系：替代分析

背景：替代摄入不同类型的蛋白质可能与心血管风险因素和炎症生物标志物有关。然而，针对老年人的研究很少，研究结果也相互矛盾。目的：我们决定研究用植物蛋白替代动物蛋白与老年男性心血管风险因素和炎症生物标志物之间的关系。方法：本次横断面研究从伊朗德黑兰南部的健康中心选取了 357 名老年男性。他们提供了参与研究的书面同意书。我们使用经过验证的可靠食物频率问卷（FFQ）来评估饮食摄入量。我们测量了所有生化因子，如血脂、空腹血糖（FBS）、高敏C反应蛋白（hs-CRP）、白细胞介素6（IL6）、肿瘤坏死因子-α（TNF-α）。此外，还评估了腰围（WC）和血压（BP）。使用 STATA 进行替代分析来研究上述关联。结果：用植物蛋白替代动物蛋白对腰围（OR：-4.28；95% CI：-8.51，-0.62；Ptrend = 0.047）和低密度脂蛋白/高密度脂蛋白（OR：-0.26；95% CI：-0.48，-0.05；Ptrend = 0.018）有显著的益处。结论：在老年男性中，用植物蛋白替代动物蛋白与一些心血管风险因素（包括腹围和低密度脂蛋白/高密度脂蛋白）有良好的相关性，但与炎症生物标志物没有显著的相关性。

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来源期刊

Nutrition and Healthy Aging Agricultural and Biological Sciences-Food Science

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： Nutrition and Healthy Aging is an international forum for research on nutrition as a means of promoting healthy aging. It is particularly concerned with the impact of nutritional interventions on the metabolic and molecular mechanisms which modulate aging and age-associated diseases, including both biological responses on the part of the organism itself and its micro biome. Results emanating from both model organisms and clinical trials will be considered. With regards to the latter, the journal will be rigorous in only accepting for publication well controlled, randomized human intervention trials that conform broadly with the current EFSA and US FDA guidelines for nutritional clinical studies. The journal will publish research articles, short communications, critical reviews and conference summaries, whilst open peer commentaries will be welcomed.