Effect of intra-articular injection of sodium hyaluronate on knee function and inflammatory state in knee osteoarthritis patients

Pub Date : 2024-05-10 DOI:10.4314/tjpr.v23i4.14

Lei Zhu, Yuxi Wei, Jun Zhang

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Abstract

Purpose: To investigate the effect of intra-articular sodium hyaluronate injections in knee osteoarthritis (KOA) patients. Methods: 110 patients with KOA admitted to Renmin Hospital, Hubei University of Medicine, Shiyan, China from September 2019 and October 2021 were enrolled in this study. Each patient was assigned a number based on the time of admission, and the patients were randomly divided into control and study groups. Total effectiveness (efficacy), and visual analog scale (VAS) scores in both groups were evaluated. Also, the levels of inflammatory factors, viz, IL-6, TNF-α, and TLR4 were investigated using enzyme-linked immunosorbent assay (ELISA) Results: The total effectiveness in the study group was significantly higher compared to control group (p < 0.05), while the visual analog scale (VAS) scores of the study group were significantly lower than those of the control group one week and three months after treatment (p < 0.05). Conclusion: Intra-articular injection of sodium hyaluronate relieves pain, restores knee function, and reduces joint inflammation. Future long-term studies utilizing a larger number of patients from multiple centers will be required to validate treatment effects, potential for relapse, and recurrence of symptoms.

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关节内注射透明质酸钠对膝关节骨性关节炎患者膝关节功能和炎症状态的影响

目的：探讨膝关节骨性关节炎（KOA）患者关节内注射透明质酸钠的效果。方法：选取2019年9月至2021年10月湖北医药学院附属人民医院收治的110例KOA患者作为研究对象。根据入院时间为每位患者分配一个编号，并将患者随机分为对照组和研究组。对两组患者的总有效率（疗效）和视觉模拟量表（VAS）评分进行评估。此外，还使用酶联免疫吸附试验（ELISA）检测了炎症因子（即 IL-6、TNF-α 和 TLR4）的水平：研究组的总有效率明显高于对照组（P < 0.05），而研究组在治疗一周后和三个月后的视觉模拟量表（VAS）评分明显低于对照组（P < 0.05）。结论关节内注射透明质酸钠可缓解疼痛、恢复膝关节功能并减轻关节炎症。未来的长期研究需要利用来自多个中心的更多患者，以验证治疗效果、复发可能性和症状复发情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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