Unravelling the complex interplay: environmental mixtures and breast cancer risk

Q4 Medicine
M. Jabran, I. Rangraze
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引用次数: 0

Abstract

Background. Globally, breast cancer ranks as the fourth most frequent reason for mortality when it comes to fatalities from cancer. The worrisome increases in rates of occurrence and death observed during the previous thirty years or more can be linked to several factors, such as changes in risk factor profiles, advancements in cancer registration, and the development of more effective detection technology. A strong association exists between the progression of metastasis and the mortality rate in breast cancer, with environmental pollutants seemingly contributing to this phenomenon. This association prompts a significant inquiry into the mechanisms that regulate the formation of metastases due to environmental and chemical contaminants. The impact of pollutants and chemical substances on communication pathways, which are essential for the growth and spread of tumor cells, among the numerous possible risk factors is gaining increasing focus. Material and methods. scientific research on environmental variables and additional factors linked to breast carcinoma was located and reviewed using engines such as the PubMed database, the MEDLINE database the Scopus database, and Google Scholar, among others, with search terms like “Breast Cancer”, “Risk components”, “Chemical exposures”, “Environmental toxic exposure”, “Disease progression”, “Bisphenol-A”, “Heavy metallic materials”, and “Food preparations”. Results. This literature aimed to present a thorough overview of the existing data on the impact of environmental and chemical toxins on breast cancer and as a result, a significant relationship between these toxins and breast cancer and its metastatic potential was discovered in more depth. Conclusion. In conclusion, breast cancer's complexity demands a holistic approach encompassing genetic, environmental, and early detection strategies. advancements in stem cell biology and gene identification enhance our understanding. Yet, dissemination remains a key challenge. Environmental toxins play a significant role, necessitating further epidemiological and molecular investigations to mitigate breast cancer's global impact.
揭示复杂的相互作用:环境混合物与乳腺癌风险
背景。在全球范围内,乳腺癌位居癌症死亡原因的第四位。在过去三十多年里,乳腺癌的发病率和死亡率都出现了令人担忧的增长,这与多种因素有关,如风险因素的变化、癌症登记的进步以及更有效检测技术的发展。转移的进展与乳腺癌的死亡率之间存在着密切的联系,而环境污染物似乎是造成这一现象的原因之一。这种关联促使人们对环境和化学污染物导致转移的形成机制进行深入探究。在众多可能的风险因素中,污染物和化学物质对肿瘤细胞生长和扩散所必需的通讯途径的影响日益受到关注。使用 PubMed 数据库、MEDLINE 数据库、Scopus 数据库和 Google Scholar 等引擎,以 "乳腺癌"、"风险因素"、"化学暴露"、"环境毒物暴露"、"疾病进展"、"双酚 A"、"重金属材料 "和 "食品制剂 "等为检索词,查找并审查了与乳腺癌相关的环境变量和其他因素的科学研究。结果。该文献旨在全面概述环境和化学毒素对乳腺癌影响的现有数据,从而更深入地发现这些毒素与乳腺癌及其转移潜力之间的重要关系。结论总之,乳腺癌的复杂性要求我们采取包括遗传、环境和早期检测策略在内的综合方法。然而,扩散仍然是一个关键挑战。环境毒素在其中扮演着重要角色,因此有必要开展进一步的流行病学和分子研究,以减轻乳腺癌对全球的影响。
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来源期刊
Siberian journal of oncology
Siberian journal of oncology Medicine-Oncology
CiteScore
0.40
自引率
0.00%
发文量
117
审稿时长
8 weeks
期刊介绍: The main objectives of the journal are: -to promote the establishment of Russia’s leading worldwide positions in the field of experimental and clinical oncology- to create the international discussion platform intended to cover all aspects of basic and clinical cancer research, including carcinogenesis, molecular biology, epidemiology, cancer prevention, diagnosis and multimodality treatment (surgery, chemotherapy, radiation therapy, hormone therapy), anesthetic management, medical and social rehabilitation, palliative care as well as the improvement of life quality of cancer patients- to encourage promising young scientists to be actively involved in cancer research programs- to provide a platform for researches and doctors all over the world to promote, share, and discuss various new issues and developments in cancer related problems. (to create a communication platform for the expansion of cooperation between Russian and foreign professional associations).- to provide the information about the latest worldwide achievements in different fields of oncology The most important tasks of the journal are: -to encourage scientists to publish their research results- to offer a forum for active discussion on topics of major interest - to invite the most prominent Russian and foreign authors to share their latest research findings with cancer research community- to promote the exchange of research information, clinical experience, current trends and the recent developments in the field of oncology as well as to review interesting cases encountered by colleagues all over the world- to expand the editorial board and reviewers with the involvement of well-known Russian and foreign experts- to provide open access to full text articles- to include the journal into the international database- to increase the journal’s impact factor- to promote the journal to the International and Russian markets
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