On the issue of repeated implantation failures with assisted reproductive technologies

Abstract

Embryo implantation is the first key step of a successful pregnancy, but implantation failures in patients undergoing assisted reproductive technology (ART) programs remains quite common. The main known factors of repeated implantation failures (RIF) in patients undergoing ART are unhealthy lifestyle, genetic factor, uterus pathology, endometriosis and adenomyosis, thrombophilia, and also male factor and embryonic factors. RIF factors and ways to overcome them receive much attention from researchers. However, although many possible RIF causes have been identified, much remains unknown regarding the etiology and management of this condition. In clinical practice, studies and interventions are often used without clear scientific rationale or convincing evidence of their effectiveness due to the lack of standardization of diagnostic and treatment methods. An effective strategy for treating RIF risk factors is necessary to increase the chances of successful pregnancy in assisted reproductive technology programs.