BF3·OEt2 Mediated (3+2) Cycloaddition Reactions of DACs with Cyanamides: Access to Cyclic Amidines

Synthesis Pub Date : 2024-05-13 DOI:10.1055/a-2323-0721
B. Gopal, Prasoon Raj Singh, Shubham Bhatt, Avijit Goswami
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Abstract

A BF3·OEt2 promoted facile synthesis of cyclic amidines has been developed via the (3+2)-cycloaddition of cyanamides with donor-acceptor cyclopropanes (DACs). In addition to this, the protocol has been successfully extended to construct dimerized amidine derivative and gram-scale synthesis with great efficiency.

Abstract Image

BF3-OEt2 介导的 DAC 与氰酰胺的 (3+2) 环加成反应:获得环酰胺
在 BF3-OEt2 的促进下,通过氰酰胺与供体-受体环丙烷(DACs)的 (3+2)-cycloaddition 反应,开发出了一种简便的环脒合成方法。除此以外,该方案还成功地扩展到了二聚脒衍生物的构建以及克级规模的高效合成。
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