The Use of Nanofibers in Regenerative Endodontic Therapy—A Systematic Review

Fibers Pub Date : 2024-05-13 DOI:10.3390/fib12050042
Sebastian Candrea, A. Muntean, Anida-Maria Băbțan, Antonia Boca, C. Feurdean, I. R. Bordea, A. B. Boșca, A. Ilea
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Abstract

Pulpal pathology in young permanent teeth, caused by dental caries or trauma, can lead to disruption of root formation, leaving the tooth with an uncertain prognosis. Current therapies for such cases present a number of limitations; thus, the aim of this article is to provide an overview on the use of nanofibers in endodontics. The search was conducted on two databases and eight articles met the inclusion criteria for this systematic review. Data on nanofiber production and fiber characteristics were extracted and systematized in tables. Moreover, the ability of novel scaffolds to deliver either drugs or different therapeutic agents without interfering with the products’ characteristics is analyzed from the in vitro and in vivo data. The potential for nanofiber-based scaffolds to induce cellular differentiation and overcome the limitations of classic regenerative endodontic treatment is also discussed.
纳米纤维在牙髓再生疗法中的应用--系统性综述
由龋齿或外伤引起的年轻恒牙牙髓病变可导致牙根形成中断,使牙齿的预后不确定。目前治疗此类病例的方法存在许多局限性;因此,本文旨在概述纳米纤维在牙髓病学中的应用。本文在两个数据库中进行了搜索,共有八篇文章符合本系统综述的纳入标准。文章提取了纳米纤维的生产数据和纤维特征,并将其系统化地整理成表格。此外,还根据体外和体内数据分析了新型支架在不影响产品特性的情况下输送药物或不同治疗剂的能力。此外,还讨论了基于纳米纤维的支架在诱导细胞分化和克服传统牙髓再生治疗的局限性方面的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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