Evaluation of the value of combined detection of tumor markers CA724, carcinoembryonic antigen, CA242, and CA19-9 in gastric cancer

World Journal of Gastrointestinal Oncology Pub Date : 2024-05-15 DOI:10.4251/wjgo.v16.i5.1737

Chong-Mei Zhou, Shao-Hua Zhao

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Abstract

BACKGROUND Gastric cancer is a global health concern that poses a significant threat to human well-being. AIM To detecting serum changes in carcinoembryonic antigen (CEA), carbohydrate antigens (CA) 724, CA242, and CA19-9 expression among patients with gastric cancer. METHODS Eighty patients diagnosed with gastric cancer between January 2020 and January 2023 were included in the observation group, while 80 patients with benign gastric diseases were included in the control group. Both groups were tested for tumor markers (CA724, CEA, CA242, and CA19-9]. Tumor marker indicators (CA724, CEA, CA242, and CA19-9) were compared between the two groups, assessing positive rates of tumor markers across various stages in the observation group. Additionally, single and combined detection of various tumor markers were examined. RESULTS The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value observed for the combined detection of CA724, CEA, CA242, and CA19-9 were higher than those of CA724, CEA, CA242, and CA19-9 individually. Therefore, the combined detection of CA724, CEA, CA242, and CA19-9 has a high diagnostic accuracy and could reduce the occurrence of missed or misdiagnosed cases, facilitating the early diagnosis and treatment of patients. CONCLUSION CA724, CEA, CA242, and CA19-9 serum levels in gastric cancer patients significantly surpassed those in non-gastric cancer patients (P < 0.05). Their combined detection can improve the diagnostic accuracy for gastric cancer, warranting clinical promotion.

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联合检测胃癌肿瘤标志物 CA724、癌胚抗原、CA242 和 CA19-9 的价值评估

背景胃癌是全球关注的健康问题，对人类福祉构成重大威胁。目的检测胃癌患者血清中癌胚抗原（CEA）、碳水化合物抗原（CA）724、CA242 和 CA19-9 表达的变化。方法将 2020 年 1 月至 2023 年 1 月期间确诊的 80 例胃癌患者纳入观察组，将 80 例良性胃病患者纳入对照组。两组患者均接受肿瘤标志物（CA724、CEA、CA242 和 CA19-9）检测。比较两组患者的肿瘤标志物指标（CA724、CEA、CA242和CA19-9），评估观察组各分期肿瘤标志物的阳性率。此外，还对各种肿瘤标志物的单一检测和联合检测进行了研究。结果联合检测 CA724、CEA、CA242 和 CA19-9 的敏感性、特异性、准确性、阳性预测值和阴性预测值均高于单独检测 CA724、CEA、CA242 和 CA19-9。因此，联合检测 CA724、CEA、CA242 和 CA19-9 具有较高的诊断准确性，可减少漏诊或误诊病例的发生，有利于患者的早期诊断和治疗。结论胃癌患者的 CA724、CEA、CA242 和 CA19-9 血清水平明显高于非胃癌患者（P < 0.05）。它们的联合检测可提高胃癌诊断的准确性，值得临床推广。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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World Journal of Gastrointestinal Oncology

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