Retinopathy of prematurity in multiple births versus single births preterm, extremely preterm infants

Abstract

The purpose of the study was to compare the retinopathy of prematurity in preterm, extremely preterm infants between multiple and single births.It was a hospital – based cross sectional comparative study conducted among preterm 28 - ≤37 weeks of gestational age, extremely preterm ≤ 28 weeks of gestational age at delivery of multiple and single births. Data on Gestational age, birth weight, birth order (single/multiple), Risk factors, Refractive status, and Treatment type were noted. Ophthalmological findings were performed routinely at 4 weeks and repeated later depending upon the severity. 49 infants were involved in this study; 22 were born as singletons and 27 as multiples. Our results show 2.0% of subject in stage 1, 18.4% in stage 2, 8.2% in stage 3, 2.0% in stage 4 substantially corresponds with the severity of retinopathy of prematurity due to lower gestational week and lower birth weight. Multiple birth infants statistically had 6.1% in stage 1, 18.4% in stage 2, 8.2% in stage 3, 2.0% in stage 4 retinopathy of prematurity than single birth infants. Risk factor results indicates necrotizing enterocolitis (33.3% in stage 2), oxygen (35.5% in stage 2 and 16.1% in stage 3), sepsis (37.9%, and 20.7% in stage 3), and continuous positive airway pressure (44.4% in stage 2 and 11.1% in stage 3) Compound hyperopic astigmatism was the most typical refractive error in both births. Laser treatment accounts for 18.1% in both groups. This study showed a significant correlation with ROP development in multiple births.