Seroprevalence of Hepatitis A virus and Hepatitis E virus in patients presenting with acute viral hepatitis: A retrospective study of 2-years at tertiary care Hospital, Himachal Pradesh in Northern India

Indian Journal of Microbiology Research Pub Date : 2024-05-15 DOI:10.18231/j.ijmr.2024.007

Anuradha Sood, Ankita Sharma, Narender Kumar

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Abstract

: Hepatitis-A virus and Hepatitis-E virus are spread enterically, resulting in acute viral hepatitis (AVH) in developing countries. Fecal-oral transmitted hepatitis cause major health problems in our country. The aim of present study is to determine the seroprevalence of HAV and HEV in AVH patients attending the tertiary care hospital at Dr. Rajendra Prasad Govt. Medical College Kangra at Tanda, Himachal Pradesh (DRPGMC). Insufficient data makes it difficult to determine an accurate prevalence of illness in this region of India.: The Viral Research and Diagnostic Laboratory (VRDL), in the Department of Microbiology at DRPGMC Tanda, Himachal Pradesh, consolidated retrospective data of 2-years duration. The study population included 784 serum samples received from outdoor and indoor patients were considered in the study.: Of the 784 serum samples that were chosen for our study, HAV and HEV reactive patients showed a seroprevalence of 11.20% and 1.80% respectively. During two years of the study, the co-infection rate of HAV and HEV in patients with acute viral hepatitis was 0.5%. Compared to females (31.80% and 42%), males reported higher seroprevalence of HAV (68.10%) and HEV (57.10%). Further data shows that HAV infection was observed in all age groups and the highest prevalence was reported in the age range from 11 to 20 years. The HEV infection was not observed in the pediatric age groups, it was only observed in adults. Maximum prevalence of HEV was reported in the age group of 21-30 years. The highest number of reactive cases was recorded in the month of August and September.: We found that the prevalence of HAV is significantly higher than that of HEV during two years of study period. In this study, we observed that HAV is more predominant in males as compare to females.HEV infections were only observed in adults.

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急性病毒性肝炎患者的甲型肝炎病毒和戊型肝炎病毒血清流行率：印度北部喜马偕尔邦三级医院为期两年的回顾性研究

:甲型肝炎病毒和戊型肝炎病毒通过肠道传播，在发展中国家导致急性病毒性肝炎（AVH）。粪口传播肝炎在我国造成了严重的健康问题。本研究旨在确定在喜马偕尔邦坦达的拉金德拉-普拉萨德博士政府医学院康拉分院（DRPGMC）三级护理医院就诊的 AVH 患者中 HAV 和 HEV 的血清流行率。由于数据不足，很难确定印度这一地区的准确发病率。喜马偕尔邦坦达 DRPGMC 微生物学系的病毒研究与诊断实验室（VRDL）整合了为期两年的回顾性数据。研究对象包括从室外和室内患者处采集的 784 份血清样本：在我们选取的 784 份血清样本中，HAV 和 HEV 反应患者的血清阳性率分别为 11.20% 和 1.80%。在两年的研究中，急性病毒性肝炎患者的 HAV 和 HEV 合并感染率为 0.5%。与女性（31.80% 和 42%）相比，男性的 HAV（68.10%）和 HEV（57.10%）血清阳性率更高。进一步的数据显示，所有年龄组均可观察到 HAV 感染，11 至 20 岁年龄组的感染率最高。在儿科年龄组中未发现 HEV 感染，仅在成人中发现。21-30 岁年龄组的 HEV 感染率最高。8月和9月的反应性病例数最多：我们发现，在两年的研究期间，HAV 的流行率明显高于 HEV。在这项研究中，我们发现与女性相比，男性更容易感染 HAV。

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Indian Journal of Microbiology Research

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