Genetic variants in miR-146a and miR-196a2 in endometriosis: a Brazilian study

Revista da Associação Médica Brasileira Pub Date : 2024-05-17 DOI:10.1590/1806-9282.20231382

Gabriela Caramano de Oliveira, M. T. R. Cintra, Marco Fábio Prata Lima, Mariana Kefalas Oliveira Gomes, A. B. T. D. Marqui

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Abstract

SUMMARY OBJECTIVE: The aim of this study was to determine the allelic and genotypic frequencies of the polymorphisms, rs2910164 miR-146a and rs11614913 miR-196a2, by investigating their association with endometriosis. METHODS: This is a case–control study performed with approximately 120 women. The polymorphisms were determined by real-time polymerase chain reaction. For the statistical analysis, the chi-square and logistic regression tests were used. RESULTS: There were no significant differences in the genotype and allele frequencies of rs2910164 and rs11614913 between cases and controls. The frequencies in both polymorphisms are in accordance with Hardy-Weinberg equilibrium regarding miR-146a (patients: χ2=1.64, p=0.20; controls: χ2=0.25, p=0.62) and miR-196a2 (patients: χ2=0.58, p=0.44; controls: χ2=2.78, p=0.10). No relationship was observed between rs2910164 and rs11614913 and endometriosis in the inheritance models analyzed. CONCLUSION: In this study, our results show that the studied polymorphisms are not implicated in the development of endometriosis.

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子宫内膜异位症中 miR-146a 和 miR-196a2 的基因变异：一项巴西研究

摘要目的：本研究旨在通过调查多态性 rs2910164 miR-146a 和 rs11614913 miR-196a2 与子宫内膜异位症的关系，确定其等位基因和基因型频率。方法：这是一项病例对照研究，研究对象为约 120 名妇女。多态性是通过实时聚合酶链反应测定的。统计分析采用了卡方检验和逻辑回归检验。结果：病例和对照组之间 rs2910164 和 rs11614913 的基因型和等位基因频率没有明显差异。在 miR-146a （患者：χ2=1.64，P=0.20；对照组：χ2=0.25，P=0.62）和 miR-196a2 （患者：χ2=0.58，P=0.44；对照组：χ2=2.78，P=0.10）方面，两个多态性的频率均符合 Hardy-Weinberg 平衡。在分析的遗传模型中，未观察到 rs2910164 和 rs11614913 与子宫内膜异位症之间的关系。结论：本研究结果表明，所研究的多态性与子宫内膜异位症的发生无关。

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Revista da Associação Médica Brasileira

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