Emerging targets in lipid metabolism for cancer therapy.

IF 13.9 1区医学 Q1 PHARMACOLOGY & PHARMACY

Trends in pharmacological sciences Pub Date : 2024-06-01 Epub Date: 2024-05-17 DOI:10.1016/j.tips.2024.04.007

Alexander R Terry, Nissim Hay

引用次数: 0

Abstract

Cancer cells perturb lipid metabolic pathways for a variety of pro-tumorigenic functions, and deregulated cellular metabolism is a hallmark of cancer cells. Although alterations in lipid metabolism in cancer cells have been appreciated for over 20 years, there are no FDA-approved cancer treatments that target lipid-related pathways. Recent advances pertaining to cancer cell fatty acid synthesis (FAS), desaturation, and uptake, microenvironmental and dietary lipids, and lipid metabolism of tumor-infiltrating immune cells have illuminated promising clinical applications for targeting lipid metabolism. This review highlights emerging pathways and targets for tumor lipid metabolism that may soon impact clinical treatment.

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用于癌症治疗的脂质代谢新目标。

癌细胞会扰乱脂质代谢途径，从而产生多种促癌功能，而细胞代谢紊乱是癌细胞的一大特征。尽管人们认识到癌细胞中脂质代谢的改变已有 20 多年的历史，但目前还没有针对脂质相关途径的 FDA 批准的癌症治疗方法。最近在癌细胞脂肪酸合成（FAS）、脱饱和和吸收、微环境和饮食脂质以及肿瘤浸润免疫细胞的脂质代谢方面取得的进展为靶向脂质代谢的临床应用带来了希望。本综述重点介绍了可能很快影响临床治疗的新兴肿瘤脂质代谢途径和靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in pharmacological sciences 医学-药学

CiteScore

23.90

自引率

0.70%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research. The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics. Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles. Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.