Luis A Sierra, Amy Wynn, Ella Lanzaro, Katya Dzekon, Aine Russell, Mark Halko, Daniel O Claassen, Samuel Frank, Ciaran M Considine, Simon Laganiere
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引用次数: 0
Abstract
Background: Huntington's disease (HD) is a neurodegenerative disorder marked by cognitive impairment, movement abnormalities, and behavioral disturbances. The Stroop Color Word Test (SCWT) is a widely used tool to detect cognitive decline in HD. Variations in SCWT formats-horizontal (original) and vertical (Golden)-may influence performance, given HD's impact on cognitive and oculomotor abilities.
Objective: This study aimed to compare the effectiveness of the horizontal and Golden vertical SCWT formats in detecting cognitive decline in HD, and to determine how performance may have been influenced by eye movement abnormalities.
Methods: Forty-five participants with genetically confirmed HD were recruited. Both SCWT formats were administered to each participant in a counterbalanced fashion. Individual performance of all three sections on each format was standardized across 2 different norms. Raw and normed scores on each variation were compared and correlated with eye movement ratings on the Unified Huntington's Disease Rating Scale.
Results: The Golden variation elicited significantly slower responses, particularly in the Word Reading section, across two benchmark norms. Statistical analysis revealed significant performance differences between the two formats. Correlations between vertical eye movement ratings and performance on the Golden SCWT were highly significant, highlighting the impact of oculomotor coordination on cognitive assessments in HD.
Conclusion: This study underscores the importance of considering test format in cognitive assessments for HD. The Golden vertical SCWT demonstrates increased sensitivity in detecting deficits in HD, possibly linked to vertical saccade abnormalities. These insights are important for improving the sensitivity of cognitive assessments and monitoring disease progression in HD research and clinical practice.
背景：亨廷顿氏病（Huntington's disease，HD）是一种神经退行性疾病，以认知障碍、运动异常和行为紊乱为特征。施特罗普颜色词测试（SCWT）是检测亨廷顿氏病认知能力下降的一种广泛使用的工具。鉴于 HD 对认知能力和眼球运动能力的影响，SCWT 格式--水平格式（原始格式）和垂直格式（金色格式）--的不同可能会影响测试成绩：本研究旨在比较水平和金色垂直 SCWT 格式在检测 HD 患者认知能力下降方面的有效性，并确定眼球运动异常可能对测试成绩产生的影响：招募了 45 名经基因证实患有 HD 的参与者。以平衡方式对每位参与者进行两种 SCWT 测试。每种格式的所有三个部分的个人成绩在两个不同的标准中进行标准化。对每种变异的原始分数和标准分数进行比较，并与亨廷顿氏病统一评定量表的眼球运动评分相关联：在两个基准标准中，"黄金 "变体引起的反应明显较慢，尤其是在单词阅读部分。统计分析显示，两种格式的成绩差异明显。眼球垂直运动评分与金色 SCWT 成绩之间的相关性非常显著，突出表明了眼球运动协调对 HD 认知评估的影响：本研究强调了在进行 HD 认知评估时考虑测试形式的重要性。金色垂直SCWT在检测HD缺陷方面显示出更高的灵敏度，这可能与垂直囊回异常有关。这些见解对于提高认知评估的灵敏度以及在 HD 研究和临床实践中监测疾病进展非常重要。
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