Advances in preclinical approaches for intravesical therapy of bladder cancer.

IF 2.1 3区医学 Q2 UROLOGY & NEPHROLOGY

Current Opinion in Urology Pub Date : 2024-07-01 Epub Date: 2024-05-16 DOI:10.1097/MOU.0000000000001186

Sreekanth Reddy Obireddy, Wing-Fu Lai

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引用次数: 0

Abstract

Purpose of review: The purpose of this review is to explore new strategies to treat bladder cancer. This article addresses challenges and opportunities in intravesical therapy of bladder cancer.

Recent findings: The review examines the latest advances in the development of preclinical approaches for intravesical therapy of bladder cancer. It discusses strategies to improve drug delivery efficiency by using synthesized diverse carriers. Immunotherapy with protein aggregate magnesium-ammonium phospholinoleate-palmitoleate anhydride has been shown to be more effective than intravesical Bacillus Calmette-Guerin. Novel drug delivery systems such the urinary drug-disposing strategy and intravesical nanoparticle formulations improve the drug delivery efficiency while minimizing adverse reactions. Innovative imaging techniques using near-infrared fluorescence probes and multifunctional nano-transformers enable real-time detection and targeted therapy in bladder cancer treatment.

Summary: Treatment of bladder cancer is clinically challenging. However, recent progress in drug delivery technologies shows promise. Optimizing these technologies helps improve patient outcomes, and facilitates clinical translation of different treatment modalities.

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膀胱癌膀胱内治疗临床前方法的进展。

综述目的：本综述旨在探讨治疗膀胱癌的新策略。本文探讨了膀胱癌膀胱内治疗面临的挑战和机遇：综述探讨了膀胱癌膀胱内治疗临床前方法开发的最新进展。它讨论了利用合成的多种载体提高药物输送效率的策略。与膀胱内注射卡介苗杆菌相比，使用磷脂酰酸棕榈油酸酐镁铵蛋白聚合体进行免疫治疗更有效。新型给药系统，如尿液药物排出策略和膀胱内纳米颗粒制剂，在提高给药效率的同时最大限度地减少了不良反应。使用近红外荧光探针和多功能纳米转化器的创新成像技术可在膀胱癌治疗中实现实时检测和靶向治疗。然而，最近在给药技术方面取得的进展显示出了希望。优化这些技术有助于改善患者的预后，并促进不同治疗模式的临床转化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Urology 医学-泌尿学与肾脏学

CiteScore

5.00

自引率

4.00%

发文量

140

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Urology delivers a broad-based perspective on the most recent and most exciting developments in urology from across the world. Published bimonthly and featuring ten key topics – including focuses on prostate cancer, bladder cancer and minimally invasive urology – the journal’s renowned team of guest editors ensure a balanced, expert assessment of the recently published literature in each respective field with insightful editorials and on-the-mark invited reviews.