Anti-CD38 monoclonal antibodies in multiple myeloma with gain/amplification of chromosome arm 1q: a review of the literature.

IF 3.6 3区 医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Expert Opinion on Biological Therapy Pub Date : 2024-05-01 Epub Date: 2024-05-19 DOI:10.1080/14712598.2024.2357382
Emiliano Barbieri, Enrica Antonia Martino, Elena Rivolti, Micol Quaresima, Ernesto Vigna, Antonino Neri, Fortunato Morabito, Massimo Gentile
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引用次数: 0

Abstract

Introduction: Gain/amplification of 1q (+1q) represents one of the most prevalent cytogenetic abnormalities (CAs) observed in multiple myeloma (MM). Historical studies predating the advent of anti-CD38 monoclonal antibodies (moAbs) implicated + 1q in poor prognoses, prompting its integration into novel staging systems. However, with the emergence of daratumumab and isatuximab, two pivotal anti-CD38 moAbs, the landscape of MM therapy has undergone a profound transformation.

Areas covered: This review encompasses a comprehensive analysis of diverse study methodologies, including observational investigations, clinical trials, meta-analyses, and real-world database analyses. By synthesizing these data sources, we aim to provide an overview of the current understanding of + 1q in the context of anti-CD38 moAbs therapies.

Expert opinion: Despite the paucity of available data, evidence suggests a potential mitigating effect of daratumumab on the adverse prognostic implications of + 1q. However, this benefit seems to diminish in patients harboring ≥ 4 copies or with concurrent high-risk CAs. On the other hand, isatuximab demonstrated promising outcomes in the relapsed-refractory setting for + 1q MM patients. Nevertheless, direct comparison between the two compounds is currently challenging. The current evidence firmly supports the integration of anti-CD38 moAb-based therapies as the standard of care for + 1q patients, pending further elucidation.

染色体臂1q增益/扩增的多发性骨髓瘤中的抗CD38单克隆抗体:文献综述。
导言:1q增益/扩增(+1q)是多发性骨髓瘤(MM)中最常见的细胞遗传学异常(CA)之一。在抗 CD38 单克隆抗体(moAbs)出现之前的历史研究表明,+1q 与不良预后有关,因此将其纳入了新的分期系统。然而,随着达拉曲单抗(daratumumab)和伊沙妥昔单抗(isatuximab)这两种关键的抗CD38单克隆抗体的出现,MM治疗的格局发生了深刻的变化:本综述全面分析了各种研究方法,包括观察性调查、临床试验、荟萃分析和真实世界数据库分析。通过综合这些数据来源,我们旨在概述目前在抗CD38 moAbs疗法方面对+1q的理解:尽管可用数据很少,但有证据表明达拉单抗对+ 1q的不良预后影响有潜在的缓解作用。然而,在携带≥4个拷贝或同时患有高危CA的患者中,这种益处似乎会减弱。另一方面,伊沙妥昔单抗在复发-难治性 + 1q MM 患者中显示出良好的疗效。尽管如此,对这两种化合物进行直接比较目前仍具有挑战性。目前的证据坚定地支持将基于抗 CD38 moAb 的疗法整合为 + 1q 患者的标准治疗方法,但还有待于进一步阐明。
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来源期刊
Expert Opinion on Biological Therapy
Expert Opinion on Biological Therapy 医学-生物工程与应用微生物
CiteScore
8.60
自引率
0.00%
发文量
96
审稿时长
3-8 weeks
期刊介绍: Expert Opinion on Biological Therapy (1471-2598; 1744-7682) is a MEDLINE-indexed, international journal publishing peer-reviewed research across all aspects of biological therapy. Each article is structured to incorporate the author’s own expert opinion on the impact of the topic on research and clinical practice and the scope for future development. The audience consists of scientists and managers in the healthcare and biopharmaceutical industries and others closely involved in the development and application of biological therapies for the treatment of human disease. The journal welcomes: Reviews covering therapeutic antibodies and vaccines, peptides and proteins, gene therapies and gene transfer technologies, cell-based therapies and regenerative medicine Drug evaluations reviewing the clinical data on a particular biological agent Original research papers reporting the results of clinical investigations on biological agents and biotherapeutic-based studies with a strong link to clinical practice Comprehensive coverage in each review is complemented by the unique Expert Collection format and includes the following sections: Expert Opinion – a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results; Article Highlights – an executive summary of the author’s most critical points.
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