{"title":"Platelets and inter-cellular communication in immune responses: Dialogue with both professional and non-professional immune cells.","authors":"Puja Kumari, Abhishek Ramachandra Panigrahi, Pooja Yadav, Samir Kumar Beura, Sunil Kumar Singh","doi":"10.1016/bs.apcsb.2023.12.010","DOIUrl":null,"url":null,"abstract":"<p><p>Platelets, derived from bone marrow megakaryocytes, are essential for vascular integrity and play multifaceted roles in both physiological and pathological processes within the vasculature. Despite their small size and absence of a nucleus, platelets are increasingly recognized for their diverse immune functions. Recent research highlights their pivotal role in interactions with various immune cells, including professional cells like macrophages, dendritic cells, natural killer cells, T cells, and B cells, influencing host immune responses. Platelets also engage with non-professional immune cells, contributing to immune responses and structural maintenance, particularly in conditions like inflammation and atherosclerosis. This review underscores the emerging significance of platelets as potent immune cells, elucidating their interactions with the immune system. We explore the mechanisms of platelet activation, leading to diverse functions, such as aggregation, immunity, activation of other immune cells, and pathogen clearance. Platelets have become the predominant immune cells in circulation, involved in chronic inflammation, responses to infections, and autoimmune disorders. Their immunological attributes, including bioactive granule molecules and immune receptors, contribute to their role in immune responses. Unlike professional antigen-presenting cells, platelets process and present antigens through an MHC-I-dependent pathway, initiating T-cell immune responses. This review illuminates the unique features of platelets and their central role in modulating host immune responses in health and disease.</p>","PeriodicalId":7376,"journal":{"name":"Advances in protein chemistry and structural biology","volume":"140 ","pages":"347-379"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in protein chemistry and structural biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/bs.apcsb.2023.12.010","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/4/4 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
Platelets, derived from bone marrow megakaryocytes, are essential for vascular integrity and play multifaceted roles in both physiological and pathological processes within the vasculature. Despite their small size and absence of a nucleus, platelets are increasingly recognized for their diverse immune functions. Recent research highlights their pivotal role in interactions with various immune cells, including professional cells like macrophages, dendritic cells, natural killer cells, T cells, and B cells, influencing host immune responses. Platelets also engage with non-professional immune cells, contributing to immune responses and structural maintenance, particularly in conditions like inflammation and atherosclerosis. This review underscores the emerging significance of platelets as potent immune cells, elucidating their interactions with the immune system. We explore the mechanisms of platelet activation, leading to diverse functions, such as aggregation, immunity, activation of other immune cells, and pathogen clearance. Platelets have become the predominant immune cells in circulation, involved in chronic inflammation, responses to infections, and autoimmune disorders. Their immunological attributes, including bioactive granule molecules and immune receptors, contribute to their role in immune responses. Unlike professional antigen-presenting cells, platelets process and present antigens through an MHC-I-dependent pathway, initiating T-cell immune responses. This review illuminates the unique features of platelets and their central role in modulating host immune responses in health and disease.
血小板源自骨髓巨核细胞,对血管完整性至关重要,在血管的生理和病理过程中发挥着多方面的作用。尽管血小板体积小且没有细胞核,但其多样化的免疫功能却日益得到认可。最近的研究强调了血小板在与各种免疫细胞(包括巨噬细胞、树突状细胞、自然杀伤细胞、T 细胞和 B 细胞等专业细胞)相互作用中的关键作用,从而影响宿主的免疫反应。血小板还与非专业免疫细胞相互作用,促进免疫反应和结构维护,尤其是在炎症和动脉粥样硬化等情况下。这篇综述强调了血小板作为强效免疫细胞的新兴意义,阐明了它们与免疫系统的相互作用。我们探讨了血小板活化的机制,这些机制导致了多种功能,如聚集、免疫、激活其他免疫细胞和清除病原体。血小板已成为血液循环中最主要的免疫细胞,参与慢性炎症、感染反应和自身免疫性疾病。血小板的免疫学特性,包括生物活性颗粒分子和免疫受体,有助于其在免疫反应中发挥作用。与专业的抗原递呈细胞不同,血小板通过 MHC-I 依赖途径处理和递呈抗原,启动 T 细胞免疫反应。这篇综述阐明了血小板的独特特征及其在调节宿主健康和疾病免疫反应中的核心作用。
期刊介绍:
Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.