The Incidence of Intrahepatic Cholestasis of Pregnancy and its Maternal, Fetal, and Neonatal Adverse Outcomes: A Systematic Review and Meta-Analysis

IF 2.1 4区医学 Q2 NURSING

Journal of midwifery & women's health Pub Date : 2024-05-15 DOI:10.1111/jmwh.13640

Resmiye Kaya Odabaş PhD, Yasemin Sökmen PhD, Emre Dünder PhD, Ayten Taşpınar PhD

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引用次数: 0

Abstract

Introduction

Intrahepatic cholestasis of pregnancy (ICP) is a problem with an increasing incidence and negative maternal, fetal, and neonatal consequences. This problem is becoming increasingly important. This systematic review and meta-analysis aimed to determine the incidence of ICP and its adverse maternal, fetal, and neonatal adverse outcomes based on primary research studies.

Methods

This systematic review and meta-analysis used Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guidelines and was conducted between June and September 2023 using the following keywords: obstetric cholestasis OR intrahepatic cholestasis AND pregnancy OR pregnant OR prenatal OR antenatal OR perinatal OR maternal OR fetal OR neonatal. Quality assessment of the studies was performed using the Critical Appraisal Checklists developed by the JBI Institute. Data were synthesized using meta-analysis methods.

Results

The analysis included 10 studies published between 2013 and 2023. The meta-analysis showed that the incidence of ICP was 1.7% (odds ratio [OR], 0.021; 95% CI, 0.012-0.027), whereas maternal, fetal, and neonatal adverse outcomes included cesarean birth (OR, 2.938; 95% CI, 1.467-5.881), preterm birth or preterm prelabor rupture of membranes (OR, 4.241; 95% CI, 1.996-9.009), hypertensive disorders of pregnancy (OR, 3.715; 95% CI, 1.545-8.929), maternal infection (OR, 3.301; 95% CI, 2.917-3.737), neonatal intensive care unit admission (OR, 2.715; 95% CI, 1.458-5.056), birth weight less than or equal to 2500 g (OR, 2.518; 95% CI, 1.296-4.892), and small for gestational age (OR, 1.915; 95% CI, 1.424-2.573).

Discussion

This systematic review and meta-analysis revealed that ICP has a high incidence and several maternal, fetal, and neonatal adverse outcomes. Therefore, midwives and other health professionals must be aware of these outcomes and provide appropriate care to pregnant individuals with ICP.

查看原文本刊更多论文

妊娠期肝内胆汁淤积症的发病率及其孕产妇、胎儿和新生儿不良结局：系统回顾与元分析》。

导言：妊娠期肝内胆汁淤积症（ICP）是一个发病率越来越高的问题，对孕产妇、胎儿和新生儿都有负面影响。这一问题正变得越来越重要。本系统综述和荟萃分析旨在根据主要研究确定 ICP 的发病率及其对孕产妇、胎儿和新生儿的不良后果：本系统综述和荟萃分析采用《系统综述和荟萃分析首选报告项目》（Preferred Reporting Items for Systematic Reviews and Meta-Analyses）报告指南，在 2023 年 6 月至 9 月期间进行，关键词如下：产科胆汁淤积症或肝内胆汁淤积症和妊娠或怀孕或产前或产前检查或围产期或产妇或胎儿或新生儿。研究质量评估采用 JBI 研究所开发的 "批判性评估检查表"（Critical Appraisal Checklists）。采用荟萃分析方法对数据进行了综合分析：结果：分析纳入了 2013 年至 2023 年间发表的 10 项研究。荟萃分析表明，ICP的发生率为1.7%（几率比[OR]，0.021；95% CI，0.012-0.027），而孕产妇、胎儿和新生儿的不良结局包括剖宫产（OR，2.938；95% CI，1.467-5.881）、早产或早产胎膜早破（OR，4.241；95% CI，1.996-9.009）、高血压紊乱（OR，1.021；95% CI，0.012-0.027）、早产或早产胎膜早破（OR，0.021；95% CI，0.012-0.027）。009）、妊娠高血压疾病（OR，3.715；95% CI，1.545-8.929）、产妇感染（OR，3.301；95% CI，2.917-3.737）、入住新生儿重症监护室（OR，2.715；95% CI，1.458-5.056）、出生体重小于或等于 2500 克（OR，2.518；95% CI，1.296-4.892）和胎龄小（OR，1.915；95% CI，1.424-2.573）：本系统综述和荟萃分析表明，ICP 的发病率很高，而且会对产妇、胎儿和新生儿造成多种不良后果。因此，助产士和其他医疗专业人员必须了解这些结果，并为患有 ICP 的孕妇提供适当的护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of midwifery & women's health 医学-护理

CiteScore

3.60

自引率

7.40%

发文量

103

审稿时长

6-12 weeks

期刊介绍： The Journal of Midwifery & Women''s Health (JMWH) is a bimonthly, peer-reviewed journal dedicated to the publication of original research and review articles that focus on midwifery and women''s health. JMWH provides a forum for interdisciplinary exchange across a broad range of women''s health issues. Manuscripts that address midwifery, women''s health, education, evidence-based practice, public health, policy, and research are welcomed