Eosinophilic esophagitis: Current concepts in diagnosis and management.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-01 Epub Date: 2024-05-16 DOI:10.4103/sjg.sjg_50_24

Fahad I Alsohaibani, Musthafa C Peedikayil, Mohammed A Alzahrani, Nahla A Azzam, Majid A Almadi, Evan S Dellon, Abdulrahman A Al-Hussaini

引用次数: 0

Abstract

Abstract: Eosinophilic esophagitis is an antigen-mediated chronic inflammatory disorder that has risen in incidence and prevalence over the past 2 decades. The clinical presentation is variable and consists of mainly esophageal symptoms such as dysphagia, heartburn, food impaction, and vomiting. Current management relies on dietary elimination, proton-pump inhibitors, and topical corticosteroids with different response rates and relapses after treatment discontinuation. With a better understanding of the underlying pathophysiology, many molecules emerged recently as targeted treatment including dupilumab (IL4/IL13 blocker), as the first FDA-approved biological treatment, which has changed the management paradigm.

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嗜酸性粒细胞食管炎：当前的诊断和管理理念。

摘要：嗜酸性粒细胞食管炎是一种抗原介导的慢性炎症性疾病，在过去 20 年中发病率和流行率不断上升。其临床表现多种多样，主要包括吞咽困难、烧心、食物嵌塞和呕吐等食道症状。目前的治疗主要依靠饮食控制、质子泵抑制剂和外用皮质类固醇，但反应率和停药后复发率各不相同。随着对潜在病理生理学的深入了解，最近出现了许多靶向治疗分子，其中包括杜比鲁单抗（IL4/IL13 阻断剂），它是第一种获得 FDA 批准的生物治疗方法，改变了治疗模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.