Brandon Nightingale, Megan Decker, Robert Ryan, Karolina Kaczmarczyk, Parul Jandir, Trupti Waykole, Remi Ashkar, Gabriella Harmon, Ajay Mathur, Michael Levitt
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引用次数: 0
Abstract
Multiple myeloma (MM), a malignancy involving plasma cells, disproportionately affects older adults with an average age of diagnosis of about 70 years. Oftentimes, the therapies used in the treatment of MM are associated with a risk for immunotoxicity, lowering the ability of the immune system to fight off opportunistic infections. This is an important relationship for clinicians to realize as the incidence of opportunistic infections in myeloma patients is increasing. As an example, we present a case of a patient with MM who subsequently developed a cryptococcal infection. Our paper will highlight the key details of the case as well as shed light on the importance of understanding the immunodeficiencies in this patient population. We highlight important aspects of the current literature related to MM and relate them to the associated case.
多发性骨髓瘤（MM）是一种涉及浆细胞的恶性肿瘤，多发于老年人，平均诊断年龄约为 70 岁。用于治疗多发性骨髓瘤的疗法通常都有免疫毒性风险，会降低免疫系统抵御机会性感染的能力。由于骨髓瘤患者机会性感染的发病率不断上升，临床医生必须认识到这一重要关系。举例来说，我们介绍了一例骨髓瘤患者后来患上隐球菌感染的病例。我们的论文将重点介绍该病例的关键细节，并阐明了解这类患者免疫缺陷的重要性。我们将重点介绍目前与 MM 相关文献的重要方面，并将其与相关病例联系起来。
期刊介绍：
World Journal of Oncology, bimonthly, publishes original contributions describing basic research and clinical investigation of cancer, on the cellular, molecular, prevention, diagnosis, therapy and prognosis aspects. The submissions can be basic research or clinical investigation oriented. This journal welcomes those submissions focused on the clinical trials of new treatment modalities for cancer, and those submissions focused on molecular or cellular research of the oncology pathogenesis. Case reports submitted for consideration of publication should explore either a novel genomic event/description or a new safety signal from an oncolytic agent. The areas of interested manuscripts are these disciplines: tumor immunology and immunotherapy; cancer molecular pharmacology and chemotherapy; drug sensitivity and resistance; cancer epidemiology; clinical trials; cancer pathology; radiobiology and radiation oncology; solid tumor oncology; hematological malignancies; surgical oncology; pediatric oncology; molecular oncology and cancer genes; gene therapy; cancer endocrinology; cancer metastasis; prevention and diagnosis of cancer; other cancer related subjects. The types of manuscripts accepted are original article, review, editorial, short communication, case report, letter to the editor, book review.
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