Effect of radiation therapy on lymph node fluorescence in head and neck squamous cell carcinoma after intravenous injection of indocyanine green: a prospective evaluation.

IF 3.1 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

EJNMMI Research Pub Date : 2024-05-16 DOI:10.1186/s13550-024-01106-5

Antoine Digonnet, Sophie Vankerkhove, Michel Moreau, Cécile Dekeyser, Marie Quiriny, Esther Willemse, Nicolas de Saint Aubain, Matteo Cappello, Vincent Donckier, Pierre Bourgeois

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引用次数: 0

Abstract

Background: Indocyanine green (ICG)-guided surgery has proven effective in the identification of neoplastic tissues. The effect of radiation therapy (RT) on lymph node fluorescence after intravenous injection of ICG has not been addressed yet. The objective of this study was to evaluate the influence of RT on node fluorescence during neck dissection in head and neck squamous cell carcinoma (HNSCC).

Results: Twenty-four patients with planned neck dissection for HNSCC were prospectively enrolled. Eleven were included without previous radiation therapy and 13 after RT. ICG was intravenously administered in the operating room. The resected specimen was analyzed by the pathology department to determine the status of each resected lymph node (invaded or not). The fluorescence of each resected node was measured in arbitrary units (AU) on paraffin blocs. The surface area (mm²) of all metastatic nodes and of the invaded component were measured. The values of these surface areas were correlated to fluorescence values. A total of 707 nodes were harvested, the mean fluorescence of irradiated nodes (n = 253) was 9.2 AU and of non-irradiated nodes (n = 454) was 9.6 AU (p = 0.63). Fifty nodes were invaded, with a mean fluorescence of 22 AU. The mean fluorescence values in the invaded irradiated nodes (n = 20) and the invaded non-irradiated nodes (n = 30) were 19 AU and 28 AU (p = 0.23), respectively. The surface area of metastatic nodes and of the invaded component were correlated to fluorescence values even after previous RT (p = 0.02).

Conclusion: No differences were observed between the fluorescence of irradiated and non-irradiated lymph nodes, including invaded nodes. ICG-guided surgery can be performed after failed RT.

Trial registration: EudraCT ref. 2013-004498-29, registered 29 November 2013. https://www.clinicaltrialsregister.eu/ctr-search/search?query=2013-004498-29.

查看原文本刊更多论文

静脉注射吲哚菁绿后放疗对头颈部鳞状细胞癌淋巴结荧光的影响：一项前瞻性评估。

背景：吲哚菁绿（ICG）引导的手术已被证明能有效识别肿瘤组织。静脉注射 ICG 后，放射治疗（RT）对淋巴结荧光的影响尚未得到研究。本研究旨在评估头颈部鳞状细胞癌（HNSCC）颈部清扫术中 RT 对淋巴结荧光的影响：24 名计划进行颈部切除术的 HNSCC 患者被纳入前瞻性研究。其中 11 例患者之前未接受过放射治疗，13 例患者接受过放射治疗。手术室内静脉注射 ICG。病理部门对切除的标本进行分析，以确定每个切除淋巴结的状态（是否受侵）。每个切除淋巴结的荧光以石蜡块上的任意单位（AU）为单位进行测量。测量所有转移结节和受侵部分的表面积（平方毫米）。这些表面积的值与荧光值相关。共收获了 707 个结节，照射结节（n = 253）的平均荧光值为 9.2 AU，非照射结节（n = 454）的平均荧光值为 9.6 AU（p = 0.63）。50个结节被侵袭，平均荧光值为22 AU。受侵袭的辐照结节（n = 20）和未受侵袭的辐照结节（n = 30）的平均荧光值分别为 19 AU 和 28 AU（p = 0.23）。转移性结节的表面积和受侵部分的表面积与荧光值相关，即使是在之前的 RT 之后（p = 0.02）：结论：接受过放射治疗和未接受放射治疗的淋巴结（包括受侵淋巴结）的荧光值没有差异。试验注册：EudraCT ref：EudraCT ref. 2013-004498-29, registered 29 November 2013. https://www.clinicaltrialsregister.eu/ctr-search/search?query=2013-004498-29.

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来源期刊

EJNMMI Research RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING&nb-

CiteScore

5.90

自引率

3.10%

发文量

审稿时长

13 weeks

期刊介绍： EJNMMI Research publishes new basic, translational and clinical research in the field of nuclear medicine and molecular imaging. Regular features include original research articles, rapid communication of preliminary data on innovative research, interesting case reports, editorials, and letters to the editor. Educational articles on basic sciences, fundamental aspects and controversy related to pre-clinical and clinical research or ethical aspects of research are also welcome. Timely reviews provide updates on current applications, issues in imaging research and translational aspects of nuclear medicine and molecular imaging technologies. The main emphasis is placed on the development of targeted imaging with radiopharmaceuticals within the broader context of molecular probes to enhance understanding and characterisation of the complex biological processes underlying disease and to develop, test and guide new treatment modalities, including radionuclide therapy.