Dynamical Behavior and Numerical Simulation of an Influenza A Epidemic Model with Log-Normal Ornstein–Uhlenbeck Process

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Xiaoshan Zhang, Xinhong Zhang
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Abstract

Influenza remains one of the most widespread epidemics, characterized by serious pathogenicity and high lethality, posing a significant threat to public health. This paper focuses on an influenza A infection model that includes vaccination and asymptomatic patients. The deterministic model examines the existence and local asymptotic stability of equilibria. In light of the influence of environmental disruption on the spread of disease, we develop a stochastic model in which the transmission rate follows a log-normal Ornstein–Uhlenbeck process. To demonstrate the dynamic behavior of the stochastic model, we verify the existence and uniqueness of the global positive solution. The establishment of suitable Lyapunov functions allows for the determination of sufficient conditions for the stationary distribution and extinction of the disease. Furthermore, the expression of the local density function around the quasi-endemic equilibrium is represented. Eventually, numerical simulations are conducted to support theoretical results and explore the effect of environmental noise. Our findings indicate that high noise intensity can expedite the extinction of the disease, while low noise intensity can facilitate the disease reaching a stationary distribution. This information may be valuable in developing strategies for disease prevention and control.

Abstract Image

具有对数正态 Ornstein-Uhlenbeck 过程的甲型流感流行模型的动态行为和数值模拟
流感仍是最广泛的流行病之一,具有严重的致病性和高致死率,对公共卫生构成重大威胁。本文重点研究包括疫苗接种和无症状患者在内的甲型流感感染模型。该确定性模型研究了均衡的存在性和局部渐进稳定性。鉴于环境干扰对疾病传播的影响,我们建立了一个随机模型,其中传播率遵循对数正态奥恩斯坦-乌伦贝克过程。为了证明该随机模型的动态行为,我们验证了全局正解的存在性和唯一性。通过建立合适的 Lyapunov 函数,可以确定疾病静态分布和消亡的充分条件。此外,我们还表示了准流行平衡周围的局部密度函数。最后,我们还进行了数值模拟,以支持理论结果并探索环境噪声的影响。我们的研究结果表明,高噪声强度会加速疾病的消亡,而低噪声强度则会促进疾病达到静态分布。这些信息可能对制定疾病预防和控制策略很有价值。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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