{"title":"Dynamical Behavior and Numerical Simulation of an Influenza A Epidemic Model with Log-Normal Ornstein–Uhlenbeck Process","authors":"Xiaoshan Zhang, Xinhong Zhang","doi":"10.1007/s12346-024-01051-7","DOIUrl":null,"url":null,"abstract":"<p>Influenza remains one of the most widespread epidemics, characterized by serious pathogenicity and high lethality, posing a significant threat to public health. This paper focuses on an influenza A infection model that includes vaccination and asymptomatic patients. The deterministic model examines the existence and local asymptotic stability of equilibria. In light of the influence of environmental disruption on the spread of disease, we develop a stochastic model in which the transmission rate follows a log-normal Ornstein–Uhlenbeck process. To demonstrate the dynamic behavior of the stochastic model, we verify the existence and uniqueness of the global positive solution. The establishment of suitable Lyapunov functions allows for the determination of sufficient conditions for the stationary distribution and extinction of the disease. Furthermore, the expression of the local density function around the quasi-endemic equilibrium is represented. Eventually, numerical simulations are conducted to support theoretical results and explore the effect of environmental noise. Our findings indicate that high noise intensity can expedite the extinction of the disease, while low noise intensity can facilitate the disease reaching a stationary distribution. This information may be valuable in developing strategies for disease prevention and control.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"100","ListUrlMain":"https://doi.org/10.1007/s12346-024-01051-7","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Influenza remains one of the most widespread epidemics, characterized by serious pathogenicity and high lethality, posing a significant threat to public health. This paper focuses on an influenza A infection model that includes vaccination and asymptomatic patients. The deterministic model examines the existence and local asymptotic stability of equilibria. In light of the influence of environmental disruption on the spread of disease, we develop a stochastic model in which the transmission rate follows a log-normal Ornstein–Uhlenbeck process. To demonstrate the dynamic behavior of the stochastic model, we verify the existence and uniqueness of the global positive solution. The establishment of suitable Lyapunov functions allows for the determination of sufficient conditions for the stationary distribution and extinction of the disease. Furthermore, the expression of the local density function around the quasi-endemic equilibrium is represented. Eventually, numerical simulations are conducted to support theoretical results and explore the effect of environmental noise. Our findings indicate that high noise intensity can expedite the extinction of the disease, while low noise intensity can facilitate the disease reaching a stationary distribution. This information may be valuable in developing strategies for disease prevention and control.
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.