K-means clustering of hyperpolarised 13C-MRI identifies intratumoural perfusion/metabolism mismatch in renal cell carcinoma as best predictor of highest grade
Ines Horvat-Menih, Alixander S Khan, Mary A McLean, Joao Duarte, Eva Serrao, Stephan Ursprung, Joshua D Kaggie, Andrew B Gill, Andrew N Priest, Mireia Crispin-Ortuzar, Anne Y Warren, Sarah J Welsh, Thomas J Mitchell, Grant D Stewart, Ferdia A Gallagher
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Abstract
Purpose Conventional renal mass biopsy approaches are inaccurate, potentially leading to undergrading. This study explored using hyperpolarised [1-13C]pyruvate MRI (HP 13C-MRI) to identify the most aggressive areas within the tumour of patients with clear cell renal cell carcinoma (ccRCC).
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