Design, synthesis and biological evaluation of sulfonamide derivatives of Benzothiazol-Quinoline-Pyrazoles as anticancer agents

IF 2.218 Q2 Chemistry

Chemical Data Collections Pub Date : 2024-06-01 DOI:10.1016/j.cdc.2024.101136

Perugu Edukondalu , Reddymasu Sireesha , Pushpalatha Kavuluri , Paila Suresh , Gadupudi Purna Chandra Rao , Choragudi Chandrasekhar , Rudraraju Ramesh Raju

引用次数: 0

Abstract

A new library of sulfonamide derivatives of benzothiazol-quinoline-pyrazole (11a-j) were design and synthesized and their chemical structures were confirmed by ¹HNMR, ¹³CNMR and mass spectral data. Further, all derivatives were evaluated for their preliminary anticancer applications against a panel of four human cancer cell lines such as prostate cancer cell (PC3), lung cancer cell (A549), breast cancer cell (MCF-7) and prostate cancer cell (DU-145) by using of MTT method and the obtained results were expressed with IC₅₀ µM. Most of the screened compounds were displayed moderate to good activity and etoposide utilized as positive control. Among them, five compounds 11a, 11b, 11 h, 11i and 11j were revealed more potent activities.

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作为抗癌剂的苯并噻唑-喹啉-吡唑磺酰胺衍生物的设计、合成和生物学评价

设计并合成了一个新的苯并噻唑-喹啉-吡唑磺酰胺衍生物库（11a-j），并通过 1HNMR、13CNMR 和质谱数据确认了它们的化学结构。此外，利用 MTT 法评估了所有衍生物对四种人类癌细胞系（如前列腺癌细胞（PC3）、肺癌细胞（A549）、乳腺癌细胞（MCF-7）和前列腺癌细胞（DU-145））的初步抗癌应用，所得结果以 IC50 µM 表示。以依托泊苷为阳性对照，大多数筛选出的化合物都显示出中等至良好的活性。其中，11a、11b、11 h、11i 和 11j 五种化合物具有更强的活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Data Collections Chemistry-Chemistry (all)

CiteScore

6.10

自引率

0.00%

发文量

169

审稿时长

24 days

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