Regioselective N1-methylation of 1H-tetrazoles with methyl 2,2,2-trichloroacetimidate

IF 2 3区化学 Q2 CHEMISTRY, ORGANIC

Journal of Heterocyclic Chemistry Pub Date : 2024-05-09 DOI:10.1002/jhet.4824

Sudhakar Reddy Baddam, Sudhakar Kalagara, Srinivas Ganta, Venkata Suresh Ponnuru, Balaraju Vudari, Seshadri Nalla

引用次数: 0

Abstract

An efficient, mild, and regioselective synthesis of substituted 1-methyl-1H-tetrazole using methyl 2,2,2-trichloroacetimidate is described. The substrate scope of the methodology has been established with wide variety of tetrazoles. N1-Methylated tetrazoles were synthesized with high yields (85%–97%).

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1H 四唑与 2,2,2-三氯乙酰亚氨酸甲酯的区域选择性 N1-甲基化反应

介绍了一种利用 2,2,2-三氯乙酰亚氨酸甲酯高效、温和、区域选择性合成取代的 1-甲基-1H-四氮唑的方法。该方法的底物范围已在多种四氮唑中得到确定。N1 甲基化四氮唑的合成收率很高（85%-97%）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Heterocyclic Chemistry 化学-有机化学

CiteScore

5.20

自引率

4.20%

发文量

177

审稿时长

3.9 months

期刊介绍： The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.