Determination of tinidazole by voltammetric analysis using poly (L-arginine) modified carbon paste electrode

Abstract

The current study presents the analysis of tinidazole with the aid of electrochemical analysis by utilizing 0.2 M of phosphate buffer saline and a modified carbon paste electrode. Poly(L-arginine) fabricated carbon paste electrode (PLAMCPE) was obtained by polymerizing L-arginine (L-agn) onto a bare carbon paste electrode (BCPE) by applying electropolymerisation method at pH 6.5. To examine the electrochemical response and characterization of the developed PLAMCPE, differential pulse voltammetry (DPV), cyclic voltammetry, electrochemical impedance spectroscopy, and scanning electron microscope techniques were implemented. The PLAMCPE shows significantly enhanced electrochemical sensitivity for the reduction of tinidazole compared to BCPE. At optimal working circumstances, the consequences of several parameters like scan rate, pH, concentration variation, and active surface area were analyzed. By examining the scan rate, the reaction was found to be diffusion controlled. The attained values of limit of detection was 0.0841 μM, and limit of quantification was 0.2803 μM at a linear range of 0.2 to 9.0 μM for DPV method. Moreover, PLAMCPE shows great selectivity and sensitivity at sensing tinidazole in the occurrence of other interfering organic dyes and metal ions. In addition, it demonstrates commendable repetitiveness, stability, and reproducibility. The developed electrode has a remarkable recovery rate indicating its applicability to the real sample.

Graphical abstract